Mechanics of epithelial tissues during gap closure

Begnaud S, Chen T, Delacour D, Mège RM, Ladoux B (2016)

Publication Type: Journal article, Review article

Publication year: 2016

Journal

Current Opinion in Cell Biology Elsevier

Book Volume: 42

Pages Range: 52-62

DOI: 10.1016/j.ceb.2016.04.006

Abstract

The closure of gaps is crucial to maintaining epithelium integrity during developmental and repair processes such as dorsal closure and wound healing. Depending on biochemical as well as physical properties of the microenvironment, gap closure occurs through assembly of multicellular actin-based contractile cables and/or protrusive activity of cells lining the gap. This review discusses the relative contributions of 'purse-string' and cell crawling mechanisms regulated by cell-substrate and cell-cell interactions, cellular mechanics and physical constraints from the environment.

Authors with CRIS profile

Benoit Ladoux

Involved external institutions

Institut Jacques Monod (IJM) FR France (FR) National University of Singapore (NUS) SG Singapore (SG)

How to cite

APA:

Begnaud, S., Chen, T., Delacour, D., Mège, R.M., & Ladoux, B. (2016). Mechanics of epithelial tissues during gap closure. Current Opinion in Cell Biology, 42, 52-62. https://doi.org/10.1016/j.ceb.2016.04.006

MLA:

Begnaud, Simon, et al. "Mechanics of epithelial tissues during gap closure." Current Opinion in Cell Biology 42 (2016): 52-62.

BibTeX: Download