Modeling collective cell migration in geometric confinement

Tarle V, Gauquelin E, Vedula SR, D'Alessandro J, Lim CT, Ladoux B, Gov NS (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Physical Biology Institute of Physics: Hybrid Open Access

Book Volume: 14

Article Number: 035001

Journal Issue: 3

DOI: 10.1088/1478-3975/aa6591

Abstract

Monolayer expansion has generated great interest as a model system to study collective cell migration. During such an expansion the culture front often develops 'fingers', which we have recently modeled using a proposed feedback between the curvature of the monolayer's leading edge and the outward motility of the edge cells. We show that this model is able to explain the puzzling observed increase of collective cellular migration speed of a monolayer expanding into thin stripes, as well as describe the behavior within different confining geometries that were recently observed in experiments. These comparisons give support to the model and emphasize the role played by the edge cells and the edge shape during collective cell motion.

Authors with CRIS profile

Benoit Ladoux

Involved external institutions

Weizmann Institute of Science IL Israel (IL) Institut Jacques Monod (IJM) FR France (FR) National University of Singapore (NUS) SG Singapore (SG)

How to cite

APA:

Tarle, V., Gauquelin, E., Vedula, S.R., D'Alessandro, J., Lim, C.T., Ladoux, B., & Gov, N.S. (2017). Modeling collective cell migration in geometric confinement. Physical Biology, 14(3). https://doi.org/10.1088/1478-3975/aa6591

MLA:

Tarle, Victoria, et al. "Modeling collective cell migration in geometric confinement." Physical Biology 14.3 (2017).

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