Cell shape and substrate stiffness drive actin-based cell polarity
Gupta M, Doss BL, Kocgozlu L, Pan M, Mège RM, Callan-Jones A, Voituriez R, Ladoux B (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 99
Article Number: 012412
Journal Issue: 1
DOI: 10.1103/PhysRevE.99.012412
Abstract
A general trait of living cells is their ability to exert contractile stresses on their surroundings and thus respond to substrate rigidity. At the cellular scale, this response affects cell shape, polarity, and ultimately migration. The regulation of cell shape together with rigidity sensing remains largely unknown. In this article we show that both substrate rigidity and cell shape contribute to drive actin organization and cell polarity. Increasing substrate rigidity affects bulk properties of the actin cytoskeleton by favoring long-lived actin stress fibers with increased nematic interactions, whereas cell shape imposes a local alignment of actin fibers at the cell periphery.
Authors with CRIS profile
Involved external institutions
National University of Singapore (NUS)
Singapore (SG)
Institut Jacques Monod (IJM)
France (FR)
National Center for Scientific Research / Centre national de la recherche scientifique (CNRS)
France (FR)
University of Paris 7 - Denis Diderot / Université Paris VII Denis Diderot
France (FR)
Singapore (SG)
Institut Jacques Monod (IJM)
France (FR)
National Center for Scientific Research / Centre national de la recherche scientifique (CNRS)
France (FR)
University of Paris 7 - Denis Diderot / Université Paris VII Denis Diderot
France (FR)
How to cite
APA:
Gupta, M., Doss, B.L., Kocgozlu, L., Pan, M., Mège, R.M., Callan-Jones, A.,... Ladoux, B. (2019). Cell shape and substrate stiffness drive actin-based cell polarity. Physical Review E, 99(1). https://doi.org/10.1103/PhysRevE.99.012412
MLA:
Gupta, Mukund, et al. "Cell shape and substrate stiffness drive actin-based cell polarity." Physical Review E 99.1 (2019).
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