Enhanced cell–cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk
Nguyen T, Duchesne L, Sankara Narayana GHN, Boggetto N, Fernig DD, Uttamrao Murade C, Ladoux B, Mège RM (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 38
Pages Range: 6283-6300
Journal Issue: 35
DOI: 10.1038/s41388-019-0875-6
Abstract
N-cadherin adhesion has been reported to enhance cancer and neuronal cell migration either by mediating actomyosin-based force transduction or initiating fibroblast growth factor receptor (FGFR)-dependent biochemical signalling. Here we show that FGFR1 reduces N-cadherin-mediated cell migration. Both proteins are co-stabilised at cell–cell contacts through direct interaction. As a consequence, cell adhesion is strengthened, limiting the migration of cells on N-cadherin. Both the inhibition of migration and the stabilisation of cell adhesions require the FGFR activity stimulated by N-cadherin engagement. FGFR1 stabilises N-cadherin at the cell membrane through a pathway involving Src and p120. Moreover, FGFR1 stimulates the anchoring of N-cadherin to actin. We found that the migratory behaviour of cells depends on an optimum balance between FGFR-regulated N-cadherin adhesion and actin dynamics. Based on these findings we propose a positive feed-back loop between N-cadherin and FGFR at adhesion sites limiting N-cadherin-based single-cell migration.
Authors with CRIS profile
Involved external institutions
Institut Jacques Monod (IJM)
France (FR)
Institut de Génétique & Développement de Rennes (IGDR)
France (FR)
The University of Liverpool
United Kingdom (GB)
France (FR)
Institut de Génétique & Développement de Rennes (IGDR)
France (FR)
The University of Liverpool
United Kingdom (GB)
How to cite
APA:
Nguyen, T., Duchesne, L., Sankara Narayana, G.H.N., Boggetto, N., Fernig, D.D., Uttamrao Murade, C.,... Mège, R.M. (2019). Enhanced cell–cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk. Oncogene, 38(35), 6283-6300. https://doi.org/10.1038/s41388-019-0875-6
MLA:
Nguyen, Thao, et al. "Enhanced cell–cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk." Oncogene 38.35 (2019): 6283-6300.
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