Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer

Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reis-Filho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Adams S, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Chardas A, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Fernandez-Martín C, Fineberg S, Fox SB, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hewitt S, Horlings HM, Husain Z, Irshad S, Janssen EA, Kataoka TR, Kawaguchi K, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Akturk G, Scott E, Kovács A, Lænkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Kharidehal D, Minhas FuAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rajpoot NM, Rapoport BL, Rau TT, Ribeiro JM, Rimm D, Vincent-Salomon A, Saltz J, Sayed S, Hytopoulos E, Mahon S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, Verghese GE, Viale G, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Bartlett J, Loibl S, Denkert C, Savas P, Loi S, Specht Stovgaard E, Salgado R, Gallagher WM, Rahman A (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Book Volume: 262

Pages Range: 271-288

Journal Issue: 3

DOI: 10.1002/path.6238

Abstract

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Authors with CRIS profile

Involved external institutions

University College Dublin (UCD) Ireland (IE) University of British Columbia Canada (CA) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) Centro Medico Nacional Siglo XXI Mexico (MX) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) Institut Jules Bordet Belgium (BE) Yale University United States (USA) (US) Mayo Clinic United States (USA) (US) Icahn School of Medicine at Mount Sinai United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset Sweden (SE) Manipal Hospitals India India (IN) Bristol-Myers Squibb United States (USA) (US) National Surgical Adjuvant Breast and Bowel Project Foundation (NSABP) United States (USA) (US) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Massachusetts General Hospital United States (USA) (US) F. Hoffmann-La Roche Ltd Switzerland (CH) Stavanger University Hospital Norway (NO) Mines ParisTech / École Nationale Supérieure des Mines de Paris (ENSMP) France (FR) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Matsuyama Shimin Hospital / 松山市民病院 Japan (JP) National Cancer Institute (NCI) United States (USA) (US) Sjællands Universitetshospital, Roskilde Denmark (DK) Stony Brook University (SBU) / SUNY Stony Brook United States (USA) (US) King’s College London United Kingdom (GB) University College London Hospitals (UCLH) United Kingdom (GB) Narayana Medical College & Hospital India (IN) Emory University United States (USA) (US) Hospital Clínico Universitario de Valencia Spain (ES) The University of Melbourne Australia (AU) The Institute of Cancer Research (ICR) United Kingdom (GB) Polytechnic University of Valencia / Universidad Politécnica de Valencia Spain (ES) Hospital Universitário Getúlio Vargas (HUGV) Brazil (BR) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) Albert Einstein College of Medicine United States (USA) (US) Genentech Inc. United States (USA) (US) Universitätsklinikum Düsseldorf Germany (DE) University of Birmingham United Kingdom (GB) Imagerie Moléculaire et Stratégies Théranostiques (IMoST) France (FR) Medical Oncology Centre of Rosebank South Africa (ZA) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) University of Warwick United Kingdom (GB) Sunnybrook Health Sciences Centre Canada (CA) All India Institute of Medical Sciences Raipur (AIIMS) / अखिल भारतीय आयुर्विज्ञान संस्थान रायपुर India (IN) University College London (UCL) United Kingdom (GB) Aga Khan University (AKU) / آغا خان یونیورسٹی‎ Pakistan (PK) Institut Gustave-Roussy France (FR) Ziauddin University (ZU) Pakistan (PK) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT) Northwestern University United States (USA) (US) Mater Misericordiae University Hospital (MMUH) / Ospidéal an Mater Misercordiae Ireland (IE) University of Texas MD Anderson Cancer Center United States (USA) (US) Universitätsklinikum Heidelberg Germany (DE) Tempus Labs United States (USA) (US) Fudan University / 复旦大学 China (CN) Philipps-Universität Marburg Germany (DE) Kyoto University / 京都大学 Kyōto daigaku Japan (JP) CellCarta Canada (CA) GZA Ziekenhuizen Belgium (BE) The National University of Malaysia / Universiti Kebangsaan Malaysia (UKM) Malaysia (MY) University of the Frontier / Universidad de La Frontera (UFRO) Chile (CL) New York University (NYU) United States (USA) (US) University of Surrey United Kingdom (GB) Federal University of Amazonas / Universidade Federal do Amazonas (UFAM) Brazil (BR) ICGA Foundation India (IN) Mayo Clinic Hospital United States (USA) (US) Weill Cornell Medicine United States (USA) (US) University of London United Kingdom (GB) Iwate Medical University Japan (JP) Technical University of Denmark / Danmarks Tekniske Universitet (DTU) Denmark (DK) Peter MacCallum Cancer Centre Australia (AU) Case Western Reserve University United States (USA) (US) Praava Health Bangladesh (BD) Merck & Co., Inc. / Merck Sharp & Dohme Corp (MSD) United States (USA) (US) Guy's and St Thomas' (NHS Foundation Trust) United Kingdom (GB) University of Pennsylvania (UPenn) United States (USA) (US) University of Edinburgh United Kingdom (GB) University of Michigan United States (USA) (US) University of Washington United States (USA) (US) Earle A. Chiles Research Institute at the Robert W. Franz Cancer Center United States (USA) (US) Vanderbilt University United States (USA) (US) Aakash Healthcare Super Speciality Hospital India (IN) Tehran University of Medical Sciences (TUMS) / دانشگاه علوم پزشکی تهران Iran, Islamic Republic of (IR) Georgia Institute of Technology United States (USA) (US) Stony Brook Medicine United States (USA) (US) Iuliu Hațieganu University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Iuliu Hațieganu" (UMF Cluj) Romania (RO) King Hussein Cancer Center (KHCC) / مركز الحسين للسرطان Jordan (JO) Institut Curie France (FR) Karolinska Institute Sweden (SE) Gentofte Hospital Denmark (DK) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT)

How to cite

APA:

Jahangir, C.A., Page, D.B., Broeckx, G., Gonzalez, C.A., Burke, C., Murphy, C.,... Rahman, A. (2024). Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 262(3), 271-288. https://doi.org/10.1002/path.6238

MLA:

Jahangir, Chowdhury Arif, et al. "Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 262.3 (2024): 271-288.

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