“Photo-Adrenalines”: Photoswitchable β2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling

Sink A, Gerwe H, Hübner H, Boivin-Jahns V, Fender J, Lorenz K, Gmeiner P, Decker M (2024)


Publication Type: Journal article

Publication year: 2024

Journal

DOI: 10.1002/chem.202303506

Abstract

β2-adrenergic receptor (β2-AR) agonists are used for the treatment of asthma and chronic obstructive pulmonary disease, but also play a role in other complex disorders including cancer, diabetes and heart diseases. As the cellular and molecular mechanisms in various cells and tissues of the β2-AR remain vastly elusive, we developed tools for this investigation with high temporal and spatial resolution. Several photoswitchable β2-AR agonists with nanomolar activity were synthesized. The most potent agonist for β2-AR with reasonable switching is a one-digit nanomolar active, trans-on arylazopyrazole-based adrenaline derivative and comprises valuable photopharmacological properties for further biological studies with high structural accordance to the native ligand adrenaline.

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How to cite

APA:

Sink, A., Gerwe, H., Hübner, H., Boivin-Jahns, V., Fender, J., Lorenz, K.,... Decker, M. (2024). “Photo-Adrenalines”: Photoswitchable β2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling. Chemistry - A European Journal. https://doi.org/10.1002/chem.202303506

MLA:

Sink, Alexandra, et al. "“Photo-Adrenalines”: Photoswitchable β2-Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling." Chemistry - A European Journal (2024).

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