Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study
Story L, Uus A, Hall M, Payette K, Bakalis S, Arichi T, Shennan A, Rutherford M, Hutter J (2023)
Publication Type: Journal article
Publication year: 2023
Journal
DOI: 10.1002/pd.6498
Abstract
Objectives: To evaluate changes occurring in the fetal brain prior to very preterm delivery using MRI T2* relaxometry, an indirect assessment of tissue perfusion. Method: Fetuses that subsequently delivered spontaneously <32 weeks gestation and a control cohort were identified from pre-existing datasets. Participants had undergone a 3T MRI assessment including T2* relaxometry of the fetal brain using a 2D multi-slice gradient echo single shot echo planar imaging sequence. T2* maps were generated, supratentorial brain tissue was manually segmented and mean T2* values were generated. Groups were compared using quadratic regression. Results: Twenty five fetuses that subsequently delivered <32 weeks and 67 that delivered at term were included. Mean gestation at MRI was 24.5 weeks (SD 3.3) and 25.4 weeks (SD 3.1) and gestation at delivery 25.5 weeks (SD 3.4) and 39.7 weeks (SD 1.2) in the preterm and term cohorts respectively. Brain mean T2* values were significantly lower in fetuses that subsequently delivered before 32 weeks gestation (p < 0.001). Conclusion: Alterations in brain maturation appear to occur prior to preterm delivery. Further work is required to explore these associations, but these findings suggest a potential window for therapeutic neuroprotective agents in fetuses at high risk of preterm delivery in the future.
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APA:
Story, L., Uus, A., Hall, M., Payette, K., Bakalis, S., Arichi, T.,... Hutter, J. (2023). Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study. Prenatal Diagnosis. https://doi.org/10.1002/pd.6498
MLA:
Story, Lisa, et al. "Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study." Prenatal Diagnosis (2023).
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