Nasal and sinonasal tumors formed by atypical adenomatous lesions arising in respiratory epithelial adenomatoid hamartoma/seromucinous hamartoma

Michal M, Skálová A, Hyrcza M, Laco J, Vaněček T, Rupp NJ, Michal M, Michalová K, Agaimy A, Bradová M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Virchows Archiv Springer Verlag (Germany)

DOI: 10.1007/s00428-023-03719-y

Abstract

Two benign adenomatous lesions are commonly recognized within the sinonasal tract, namely respiratory epithelial adenomatoid hamartoma (REAH) and seromucinous hamartoma (SH). We present 10 hitherto unrecognized benign polypoid nasal and sinonasal tumoriform lesions having in average 3.6 cm in largest dimension, which are histogenetically related to SH and REAH. In addition to typical structures of REAH and SH, these lesions contained an additional characteristic and slightly atypical adenomatous component, which we termed atypical sinonasal glands arising in SH (ASGSH). ASGSH often produced deep red colored secretion with peripheral clearing similar to that seen in thyroid follicles. In contrast to SH, ASGSH was endowed by both secretory and myoepithelial layers and had mostly angulated shapes with snout-like protrusions into the lumens. Both layers were formed by an irregular, disorganized, and often incomplete cell lining, which had slightly atypical cytological features without mitoses. In 3 cases, ASGSHs revealed sebaceous differentiation, and in 3 cases the stroma produced a well-differentiated cartilage. Neoplastic nature of ASGSH was supported by finding of various mutations as revealed by next generation sequencing in five cases. In two cases each, we found identical mutations in BRAF gene (Val600Glu), and RET gene (Arg912Trp), respectively and in one case FAT1 gene alteration (Pro1665Leu).

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universitätsspital Zürich (USZ) CH Switzerland (CH) Fakultní Nemocnice Plzeň CZ Czech Republic (CZ) Biopticka laborator s.r.o. CZ Czech Republic (CZ) University Hospital Hradec Králové / Fakultní Nemocnice Hradec Králové CZ Czech Republic (CZ) University of Calgary CA Canada (CA)

How to cite

APA:

Michal, M., Skálová, A., Hyrcza, M., Laco, J., Vaněček, T., Rupp, N.J.,... Bradová, M. (2023). Nasal and sinonasal tumors formed by atypical adenomatous lesions arising in respiratory epithelial adenomatoid hamartoma/seromucinous hamartoma. Virchows Archiv. https://doi.org/10.1007/s00428-023-03719-y

MLA:

Michal, Michal, et al. "Nasal and sinonasal tumors formed by atypical adenomatous lesions arising in respiratory epithelial adenomatoid hamartoma/seromucinous hamartoma." Virchows Archiv (2023).

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