TROPHY registry — status report

Thomale UW, Auer C, Spennato P, Schaumann A, Behrens P, Gorelyshev S, Bogoslovskaia E, Shulaev A, Kabanian A, Seliverstov A, Alexeev A, Ozgural O, Kahilogullari G, Schuhmann M, Jimenez-Guerra R, Wittayanakorn N, Sukharev A, Marquez-Rivas J, Linsler S, Damaty AE, Vacek P, Lovha M, Guzman R, Stricker S, Beez T, Wiegand C, Azab M, Buis D, Sáez M, Fleck S, Dziugan C, Ferreira A, Radovnicky T, Bührer C, Lam S, Sgouros S, Roth J, Constantini S, Cavalheiro S, Cinalli G, Kulkarni AV, Bock HC (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 37

Pages Range: 3549-3554

Journal Issue: 11

DOI: 10.1007/s00381-021-05258-w

Abstract

Introduction: The TROPHY registry has been established to conduct an international multicenter prospective data collection on the surgical management of neonatal intraventricular hemorrhage (IVH)-related hydrocephalus to possibly contribute to future guidelines. The registry allows comparing the techniques established to treat hydrocephalus, such as external ventricular drainage (EVD), ventricular access device (VAD), ventricular subgaleal shunt (VSGS), and neuroendoscopic lavage (NEL). This first status report of the registry presents the results of the standard of care survey of participating centers assessed upon online registration. Methods: On the standard of treatment forms, each center indicated the institutional protocol of interventions performed for neonatal post-hemorrhagic hydrocephalus (nPHH) for a time period of 2 years (Y1 and Y2) before starting the active participation in the registry. In addition, the amount of patients enrolled so far and allocated to a treatment approach are reported. Results: According to the standard of treatment forms completed by 56 registered centers, fewer EVDs (Y1 55% Y2 46%) were used while more centers have implemented NEL (Y1 39%; Y2 52%) to treat nPHH. VAD (Y1 66%; Y2 66%) and VSGS (Y1 42%; Y2 41%) were used at a consistent rate during the 2 years. The majority of the centers used at least two different techniques to treat nPHH (43%), while 27% used only one technique, 21% used three, and 7% used even four different techniques. Patient data of 110 infants treated surgically between 9/2018 and 2/2021 (13% EVD, 15% VAD, 30% VSGS, and 43% NEL) were contributed by 29 centers. Conclusions: Our results emphasize the varying strategies used for the treatment of nPHH. The international TROPHY registry has entered into a phase of growing patient recruitment. Further evaluation will be performed and published according to the registry protocol.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Heidelberg Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Kepler Universitätsklinikum (KUK) Austria (AT) Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon Italy (IT) Children's City Clinical Hospital named after Z.A. Bashlyaeva / Детская городская клиническая больница имени З.А. Башляевой Russian Federation (RU) Surgut District Clinical Center for Maternal and Child Health / Сургутский окружной клинический центр охраны материнства и детства Russian Federation (RU) Chelyabinsk Regional Clinical Hospital / Челябинская областная клиническая больница Russian Federation (RU) Ankara University / Ankara Üniversitesi Turkey (TR) Universitätsklinikum Tübingen Germany (DE) Queen Sirikit National Institute of Child Health (QSNICH) Thailand (TH) Hospitales Universitarios Virgen Macarena y Virgen del Rocío Spain (ES) Fakultní Nemocnice Plzeň Czech Republic (CZ) Volyn Regional Clinical Hospital Ukraine (UA) Universitäts-Kinderspital beider Basel (UKBB) Switzerland (CH) Heinrich-Heine-Universität Düsseldorf Germany (DE) Niels-Stensen-Kliniken GmbH Germany (DE) Damietta Specialized Hospital Egypt (EG) University of Amsterdam Netherlands (NL) Hospital Universitario La Paz Spain (ES) Universitätsmedizin Greifswald / Universitätsklinikum Greifswald Germany (DE) Ann & Robert H. Lurie Children's Hospital of Chicago United States (USA) (US) Hospital de São João / Saint John Hospital Portugal (PT) Masaryk Hospital / Masarykova nemocnice Ústí nad Labem Czech Republic (CZ) “Aghia Sophia” Children’s Hospital Greece (GR) Tel Aviv Sourasky Medical Center / Ichilov Hospital Israel (IL) Federal University of São Paulo / Universidade Federal de São Paulo (UNIFESP) Brazil (BR) The Hospital for Sick Children (SickKids) Canada (CA) Universitätsklinikum Göttingen Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE)

How to cite

APA:

Thomale, U.W., Auer, C., Spennato, P., Schaumann, A., Behrens, P., Gorelyshev, S.,... Bock, H.C. (2021). TROPHY registry — status report. Childs Nervous System, 37(11), 3549-3554. https://doi.org/10.1007/s00381-021-05258-w

MLA:

Thomale, U. W., et al. "TROPHY registry — status report." Childs Nervous System 37.11 (2021): 3549-3554.

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