Schinz D, Schmitz-Koep B, Tahedl M, Teckenberg T, Schultz V, Schulz J, Zimmer C, Sorg C, Gaser C, Hedderich DM (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 14
Article Number: 1266770
DOI: 10.3389/fpsyt.2023.1266770
Background: Cocaine use disorder (CUD) is a global health issue with severe behavioral and cognitive sequelae. While previous evidence suggests a variety of structural and age-related brain changes in CUD, the impact on both, cortical thickness and brain age measures remains unclear. Methods: Derived from a publicly available data set (SUDMEX_CONN), 74 CUD patients and 62 matched healthy controls underwent brain MRI and behavioral-clinical assessment. We determined cortical thickness by surface-based morphometry using CAT12 and Brain Age Gap Estimate (BrainAGE) via relevance vector regression. Associations between structural brain changes and behavioral-clinical variables of patients with CUD were investigated by correlation analyses. Results: We found significantly lower cortical thickness in bilateral prefrontal cortices, posterior cingulate cortices, and the temporoparietal junction and significantly increased BrainAGE in patients with CUD [mean (SD) = 1.97 (±3.53)] compared to healthy controls (p < 0.001, Cohen’s d = 0.58). Increased BrainAGE was associated with longer cocaine abuse duration. Conclusion: Results demonstrate structural brain abnormalities in CUD, particularly lower cortical thickness in association cortices and dose-dependent, increased brain age.
APA:
Schinz, D., Schmitz-Koep, B., Tahedl, M., Teckenberg, T., Schultz, V., Schulz, J.,... Hedderich, D.M. (2023). Lower cortical thickness and increased brain aging in adults with cocaine use disorder. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1266770
MLA:
Schinz, David, et al. "Lower cortical thickness and increased brain aging in adults with cocaine use disorder." Frontiers in Psychiatry 14 (2023).
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