Blood group-specific apheresis in combination with daratumumab as a rescue therapy of acute antibody-mediated rejection in a case of ABO- and human leukocyte antigen-incompatible kidney transplantation

Süsal CC, Kraft L, Ender A, Süsal C, Schwenger A, Amann KU, Böhmig GA, Schwenger V (2023)

Publication Type: Journal article

Publication year: 2023

Journal

SAGE Open Medical Case Reports SAGE Publications (UK and US)

Book Volume: 11

DOI: 10.1177/2050313X231211050

Abstract

We report a case of antibody-mediated rejection treated with the human CD38 monoclonal antibody daratumumab in a 58-year-old female patient with end-stage kidney disease due to autosomal dominant polycystic kidney disease who received an ABO- and human leukocyte antigen antibody-incompatible living donor kidney transplant. The patient experienced an episode of severe antibody-mediated rejection within the first week of transplantation. Blood-group-antibody selective immunoadsorption in combination with administration of four doses of daratumumab (each 1800 mg s.c.) led to a persistent decrease of ABO- and more interestingly donor-specific human leukocyte antigen antibody reactivity and resulted in clinical and histopathological remission with full recovery of graft function, which has remained stable until post-transplant day 212. This case illustrates the potential of targeting CD38 in antibody-mediated rejection.

Authors with CRIS profile

Kerstin Ute Amann Department of Nephropathology

Involved external institutions

Katharinenhospital Stuttgart DE Germany (DE) Koç-Universität (KU) TR Turkey (TR) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Medizinische Universität Wien AT Austria (AT)

How to cite

APA:

Süsal, C.C., Kraft, L., Ender, A., Süsal, C., Schwenger, A., Amann, K.U.,... Schwenger, V. (2023). Blood group-specific apheresis in combination with daratumumab as a rescue therapy of acute antibody-mediated rejection in a case of ABO- and human leukocyte antigen-incompatible kidney transplantation. SAGE Open Medical Case Reports, 11. https://doi.org/10.1177/2050313X231211050

MLA:

Süsal, Can C., et al. "Blood group-specific apheresis in combination with daratumumab as a rescue therapy of acute antibody-mediated rejection in a case of ABO- and human leukocyte antigen-incompatible kidney transplantation." SAGE Open Medical Case Reports 11 (2023).

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