High RIPK3 expression is associated with a higher risk of early kidney transplant failure

Wahida A, Schmaderer C, Büttner-Herold M, Branca C, Donakonda S, Haberfellner F, Torrez C, Schmitz J, Schulze T, Seibt T, Öllinger R, Engleitner T, Haller B, Steiger K, Günthner R, Lorenz G, Yabal M, Bachmann Q, Braunisch MC, Moog P, Matevossian E, Aßfalg V, Thorban S, Renders L, Späth MR, Müller RU, Stippel DL, Weichert W, Slotta-Huspenina J, von Vietinghoff S, Viklicky O, Green DR, Rad R, Amann KU, Linkermann A, Bräsen JH, Heemann U, Kemmner S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

iScience Elsevier

Book Volume: 26

Article Number: 107879

Journal Issue: 10

DOI: 10.1016/j.isci.2023.107879

Abstract

Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained from renal allografts 10 minutes after onset of reperfusion. RIPK3 was primarily detected in proximal tubular cells and distal tubular cells, both of which are affected by IRI. Time-to-event analysis revealed that high RIPK3 expression is associated with a significantly higher risk of one-year transplant failure and prognostic for one-year (death-censored) transplant failure independent of donor and recipient associated risk factors in multivariable analyses. The RIPK3 score also correlated with deceased donation, cold ischemia time and the extent of tubular injury.

Authors with CRIS profile

Maike Büttner-Herold Department of Nephropathology Kerstin Ute Amann Department of Nephropathology

Involved external institutions

Klinikum rechts der Isar DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Klinikum der Universität München DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Universität zu Köln DE Germany (DE) Universitätsklinikum Bonn DE Germany (DE) Institute for Clinical and Experimental Medicine (IKEM) CZ Czech Republic (CZ) St. Jude Children’s Research Hospital US United States (USA) (US) Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE)

How to cite

APA:

Wahida, A., Schmaderer, C., Büttner-Herold, M., Branca, C., Donakonda, S., Haberfellner, F.,... Kemmner, S. (2023). High RIPK3 expression is associated with a higher risk of early kidney transplant failure. iScience, 26(10). https://doi.org/10.1016/j.isci.2023.107879

MLA:

Wahida, Adam, et al. "High RIPK3 expression is associated with a higher risk of early kidney transplant failure." iScience 26.10 (2023).

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