Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study

Lanois CJ, Collins N, Neogi T, Guermazi A, Roemer F, LaValley M, Nevitt M, Torner J, Lewis CE, Stefanik JJ (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Osteoarthritis and Cartilage Elsevier

DOI: 10.1016/j.joca.2023.09.008

Abstract

Objective: Anterior knee pain (AKP) is associated with patellofemoral osteoarthritis (PFOA), but longitudinal studies are lacking. If AKP precedes PFOA, it may create an opportunity to identify and intervene earlier in the disease process. The purpose of this study was to examine the longitudinal relation of AKP to worsening patellofemoral (PF) cartilage over two years. Design: Participants were recruited from the Multicenter Osteoarthritis Study, a longitudinal study of individuals with or at risk for knee osteoarthritis (OA). Exclusion criteria included bilateral knee replacements, arthritis other than OA, and radiographic PFOA. At baseline, participants completed a knee pain map questionnaire and underwent knee magnetic resonance imaging (MRI). Imaging was repeated at 2-year follow-up. Exposure was presence of frequent AKP. Outcome was worsening cartilage damage in the PF joint defined as increase in MRI Osteoarthritis Knee Score from baseline to 2 years. Log-binomial models were used to calculate risk ratios (RR). Results: One knee from 1083 participants (age 56.7 ± 6.6 years; body mass index 28.0 ± 4.9 kg/m2) was included. Frequent AKP and frequent isolated AKP were present at baseline in 14.5% and 3.6%, respectively. Frequent AKP was associated with an increased risk (RR: 1.78, 95% confidence interval: 1.21, 2.62) of 2-year worsening cartilage damage in the lateral PF compartment. No association was found between frequent AKP and worsening in the medial PF joint. Conclusion: Frequent AKP at baseline was associated with worsening cartilage damage in the lateral PF joint over 2 years.

Authors with CRIS profile

Frank Roemer Medizinische Fakultät

Involved external institutions

Northeastern University US United States (USA) (US) University of Alabama at Birmingham (UAB) US United States (USA) (US) Boston University US United States (USA) (US) University of Queensland AU Australia (AU) University of Iowa US United States (USA) (US) University of California San Francisco (UCSF) US United States (USA) (US)

How to cite

APA:

Lanois, C.J., Collins, N., Neogi, T., Guermazi, A., Roemer, F., LaValley, M.,... Stefanik, J.J. (2023). Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study. Osteoarthritis and Cartilage. https://dx.doi.org/10.1016/j.joca.2023.09.008

MLA:

Lanois, C. J., et al. "Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study." Osteoarthritis and Cartilage (2023).

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