von Platen P, Abdelsamed A, Lohse A, Russ M, Wolters C, Pickerodt PA, Francis RC, Leonhardt S, Walter M (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 87
Article Number: 105532
DOI: 10.1016/j.bspc.2023.105532
Tight control of systemic oxygenation is a key component of mechanical ventilation of critically ill patients. Yet, closed-loop control remains challenging due to the non-linear, uncertain, and time-varying relationship between the inspired oxygen and the resulting patient's oxygen saturation, especially in cases of acute lung injury. This paper uses a Hammerstein model to combine a clinically validated static model incorporating ventilation-to-perfusion mismatch with uncertain linear dynamics to synthesize a robust closed-loop controller for regulating systemic oxygenation in subjects with acute lung injury. Data from an experimental lung injury model in five pigs, in combination with data augmentation, allowed modeling of the uncertainty in the system. Subsequently, gain-scheduled proportional–integral controllers were designed using the mixed-sensitivity H
APA:
von Platen, P., Abdelsamed, A., Lohse, A., Russ, M., Wolters, C., Pickerodt, P.A.,... Walter, M. (2024). Robust closed-loop control of systemic oxygenation in acute lung injury. Biomedical Signal Processing and Control, 87. https://doi.org/10.1016/j.bspc.2023.105532
MLA:
von Platen, Philip, et al. "Robust closed-loop control of systemic oxygenation in acute lung injury." Biomedical Signal Processing and Control 87 (2024).
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