The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: A report from the PanCareLIFE consortium

Scobioala S, Parfitt R, Matulat P, Byrne J, Langer T, Troschel FM, Hesping AE, Clemens E, Kaatsch P, Grabow D, Kaiser M, Spix C, Kremer LC, Calaminus G, Baust K, Kuehni CE, Weiss A, Strebel S, Kuonen R, Elsner S, Haupt R, Garré ML, Gruhn B, Kepak T, Kepakova K, Winther JF, Kenborg L, Rechnitzer C, Hasle H, Kruseova J, Luks A, Lackner H, Bielack S, Beck J, Jürgens H, van den Heuvel-Eibrink MM, Zolk O, Eich HT, am Zehnhoff-Dinnesen A (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1002/ijc.34732

Abstract

The impact of the temporal sequence by which cranial radiotherapy (CRT) and platin-based chemotherapy (PCth) are administered on sensorineural hearing loss (SNHL) in pediatric and adolescent central nervous system (CNS) and head-and-neck (HN) cancer patients has not yet been studied in detail. We examined the ototoxic effects of sequentially applied CRT and PCth. This study included children and adolescents with CNS and HN tumors who participated in the multicountry PanCareLIFE (PCL) consortium. Audiological outcomes were compared between patients who received CRT prior to PCth and those who received it afterwards. The incidence, degree and posttreatment progression of SNHL, defined as Muenster classification grade ≥MS2b, were evaluated in 141 patients. One hundred and nineteen patients were included in a time-to-onset analysis. Eighty-eight patients received CRT prior to PCth (Group 1) and 53 patients received PCth before CRT (Group 2). Over a median follow-up time of 1.6 years, 72.7% of patients in Group 1 experienced SNHL ≥ MS2b compared to 33.9% in Group 2 (P <.01). A time-to-onset analysis was performed for 74 patients from Group 1 and 45 patients from Group 2. Median time to hearing loss (HL) ≥ MS2b was 1.2 years in Group 1 and 4.4 years in Group 2 (P <.01). Thus, audiological outcomes were better for patients who received CRT after PCth than before. This finding should be further evaluated and considered within clinical practice in order to minimize hearing loss in children and adolescents with CNS and HN tumors.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Münster Germany (DE) Boyne Research Institute Ireland (IE) Universität zu Lübeck Germany (DE) Erasmus University Medical Center (MC) Netherlands (NL) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra Netherlands (NL) Istituto Giannina Gaslini Italy (IT) Universitätsklinikum Jena Germany (DE) St. Anne's University Hospital / Sv. Anny v Brně Czech Republic (CZ) Kræftens Bekæmpelse Denmark (DK) Rigshospitalet Denmark (DK) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Motol University Hospital / Fakultní nemocnice v Motole Czech Republic (CZ) Medizinische Universität Graz Austria (AT) Klinikum Stuttgart Germany (DE) Universiteit Utrecht (UU) / Utrecht University Netherlands (NL) Medizinische Hochschule Brandenburg "Theodor Fontane" / Brandenburg Medical School "Theodor Fontane" Germany (DE)

How to cite

APA:

Scobioala, S., Parfitt, R., Matulat, P., Byrne, J., Langer, T., Troschel, F.M.,... am Zehnhoff-Dinnesen, A. (2023). The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: A report from the PanCareLIFE consortium. International Journal of Cancer. https://doi.org/10.1002/ijc.34732

MLA:

Scobioala, Sergiu, et al. "The impact of the temporal sequence of cranial radiotherapy and platin-based chemotherapy on hearing impairment in pediatric and adolescent CNS and head-and-neck cancer patients: A report from the PanCareLIFE consortium." International Journal of Cancer (2023).

BibTeX: Download