Kunzelmann K, Ousingsawat J, Kraus A, Park JH, Marquardt T, Schreiber R, Buchholz B (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Book Volume: 24
Article Number: 13278
Journal Issue: 17
The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to have more in common than initially suspected, as they all participate in the pathogenic process and clinical outcomes of airway and renal diseases. In the present review, we will therefore concentrate on recent findings concerning electrolyte transport in the airways and kidneys, and the role of CFTR, SLC26A9, and the anoctamins ANO1 and ANO6. Special emphasis will be placed on cystic fibrosis and asthma, as well as renal alkalosis and polycystic kidney disease. In essence, we will summarize recent evidence indicating that CFTR is the only relevant secretory Cl− channel in airways under basal (nonstimulated) conditions and after stimulation by secretagogues. Information is provided on the expressions of ANO1 and ANO6, which are important for the correct expression and function of CFTR. In addition, there is evidence that the Cl− transporter SLC26A9 expressed in the airways may have a reabsorptive rather than a Cl−-secretory function. In the renal collecting ducts, bicarbonate secretion occurs through a synergistic action of CFTR and the Cl−/HCO
APA:
Kunzelmann, K., Ousingsawat, J., Kraus, A., Park, J.H., Marquardt, T., Schreiber, R., & Buchholz, B. (2023). Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins. International Journal of Molecular Sciences, 24(17). https://doi.org/10.3390/ijms241713278
MLA:
Kunzelmann, Karl, et al. "Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins." International Journal of Molecular Sciences 24.17 (2023).
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