Protoporphyrin IX for photodynamic therapy of brain tumours
Johansson A, Kreth FW, Ardeshiri A, Stummer W, Schnell O, Herms J, Palte G, Beyer W, Stepp H (2010)
Publication Type: Conference contribution
Publication year: 2010
Journal
Book Volume: 7715
Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Event location: BEL
ISBN: 9780819481887
DOI: 10.1117/12.854335
Abstract
Protoporphyrin IX (PpIX) displays high tumour-selective uptake following oral administration of 5-aminolaevulinic acid (ALA), a fact that is being exploited for the fluorescence-guided resection (FGR) and photodynamic therapy (PDT) of human brain malignancies. A clinical procedure for interstitial PDT (iPDT) has been established including pre-treatment planning, optical fiber insertion under stereotactic guidance and therapeutic irradiation at non-thermal fluence rates. We have previously reported on median survival in the range of 15 months and the existence of some intriguing long-term survivors (>5 years) following iPDT. Such successful treatments rely on for example sufficient light, PpIX and oxygen levels. We have investigated the absolute PpIX concentration as well as the PDT-induced photobleaching kinetics in brain tissues. Tissue samples acquired during FGR contained PpIX concentrations up to 28 μM. This observation implies that ALA-induced PpIX levels are sufficient for inducing PDT effects in viable tumour tissue upon therapeutic irradiation. However, regions of pre-existing necrosis were characterised by significantly lower photosensitiser levels. Fluorescence spectroscopy was implemented in parallel to iPDT with the aim to employ PpIX photobleaching as a tool for realtime treatment supervision and early treatment prognosis. ©2010 SPIE.
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Germany (DE)How to cite
APA:
Johansson, A., Kreth, F.W., Ardeshiri, A., Stummer, W., Schnell, O., Herms, J.,... Stepp, H. (2010). Protoporphyrin IX for photodynamic therapy of brain tumours. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. BEL.
MLA:
Johansson, A., et al. "Protoporphyrin IX for photodynamic therapy of brain tumours." Proceedings of the Biophotonics: Photonic Solutions for Better Health Care II, BEL 2010.
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