Re-irradiation in recurrent malignant glioma: Prognostic value of [ 18F]FET-PET

Niyazi M, Jansen N, Ganswindt U, Schwarz SB, Geisler J, Schnell O, Büsing K, Eigenbrod S, La Fougère C, Belka C (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Journal of Neuro-Oncology Springer Verlag (Germany)

Book Volume: 110

Pages Range: 389-395

Journal Issue: 3

DOI: 10.1007/s11060-012-0980-7

Abstract

The aim of the present study is to determine new positron emission tomography (PET) imaging-related factors predictive of progression-free survival as well as survival in patients with recurrent malignant glioma (MG) prior to and after re-irradiation. Fifty-six patients with recurrent MG who underwent re-irradiation treatment and pretherapeutic dynamic [18F]- fluoroethyl-L-tyrosine (FET)-PET scan were retrospectively analyzed. The prognostic value of different parameters, such as biological tumor volume, maximal tumor uptake (SUVmax/BG), mean tumor uptake (SUV mean/BG), as well as uptake kinetics, was evaluated. [ 18F]FET uptake kinetics was classified according to a five-point rating as category G1-2 (strongly/mainly increasing kinetics), G 3 (mixed 1:1), or G4-5 (mainly/strongly decreasing kinetics). Patients within the pretherapeutic kinetic group G4-5 had significantly worse survival than the other two groups (p = 0.01). Multivariate analysis revealed that histologic grade, Karnofsky Performance Score (KPS), and kinetic group were independent significant predictors for survival after re-irradiation. The uptake kinetics of [18F]FET-PET is an independent determinant of overall and to a lesser extent also progression-free survival. Thus, [18F]FET-PET kinetics may provide valuable additional prognostic information for treatment decisions. © Springer Science+Business Media New York 2012.

Authors with CRIS profile

Oliver Schnell

Involved external institutions

Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE)

How to cite

APA:

Niyazi, M., Jansen, N., Ganswindt, U., Schwarz, S.B., Geisler, J., Schnell, O.,... Belka, C. (2012). Re-irradiation in recurrent malignant glioma: Prognostic value of [ 18F]FET-PET. Journal of Neuro-Oncology, 110(3), 389-395. https://doi.org/10.1007/s11060-012-0980-7

MLA:

Niyazi, Maximilian, et al. "Re-irradiation in recurrent malignant glioma: Prognostic value of [ 18F]FET-PET." Journal of Neuro-Oncology 110.3 (2012): 389-395.

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