Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma

Schäfer N, Proescholdt M, Steinbach JP, Weyerbrock A, Hau P, Grauer O, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Grau S, Hänel M, Schnell O, Krex D, Vajkoczy P, Tabatabai G, Mack F, Schaub C, Tzaridis T, Nießen M, Kebir S, Leutgeb B, Urbach H, Belka C, Stummer W, Glas M, Herrlinger U (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 20

Pages Range: 975-985

Journal Issue: 7

DOI: 10.1093/neuonc/nox204

Abstract

Background The GLARIUS trial, which investigated the efficacy of bevacizumab (BEV)/irinotecan (IRI) compared with standard temozolomide in the first-line therapy of O 6 -methylguanine-DNA methyltransferase (MGMT)-nonmethylated glioblastoma, showed that progression-free survival was significantly prolonged by BEV/IRI, while overall survival was similar in both arms. The present report focuses on quality of life (QoL) and Karnofsky performance score (KPS) during the whole course of the disease. Methods Patients (n = 170) received standard radiotherapy and were randomized (2:1) for BEV/IRI or standard temozolomide. At least every 3 months KPS was determined and QoL was measured using the European Organisation for Research and Treatment of Cancer 30-item Core Quality of Life and 20-item Brain Neoplasm questionnaires. A generalized estimating equation (GEE) model evaluated differences in the course of QoL and KPS over time. Also, the time to first deterioration and the time to postprogression deterioration were analyzed separately. Results In all dimensions of QoL and KPS, GEE analyses and time to first deterioration analyses did not detect significant differences between the treatment arms. At progression, 82% of patients receiving second-line therapy in the standard arm received BEV second-line therapy. For the dimensions of motor dysfunction and headaches, time to postprogression deterioration was prolonged in the standard arm receiving crossover second-line BEV in the vast majority of patients at the time of evaluation. Conclusions GLARIUS did not find indications for a BEV-induced detrimental effect on QoL in first-line therapy of MGMT-nonmethylated GBM patients. Moreover, GLARIUS provided some indirect corroborative data supporting the notion that BEV may have beneficial effects upon QoL in relapsed GBM.

Authors with CRIS profile

Involved external institutions

Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Universität Leipzig Germany (DE) Heinrich-Heine-Universität Düsseldorf Germany (DE) Goethe-Universität Frankfurt am Main Germany (DE) Universitätsklinikum Regensburg Germany (DE) Albert-Ludwigs-Universität Freiburg Germany (DE) Universität Regensburg Germany (DE) Universitätsklinikum Freiburg Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE) Universität zu Köln Germany (DE) Georg-August-Universität Göttingen Germany (DE) Klinikum rechts der Isar Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Klinikum Chemnitz Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Technische Universität Dresden Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Eberhard Karls Universität Tübingen Germany (DE)

How to cite

APA:

Schäfer, N., Proescholdt, M., Steinbach, J.P., Weyerbrock, A., Hau, P., Grauer, O.,... Herrlinger, U. (2018). Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma. Neuro-Oncology, 20(7), 975-985. https://doi.org/10.1093/neuonc/nox204

MLA:

Schäfer, Niklas, et al. "Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma." Neuro-Oncology 20.7 (2018): 975-985.

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