Voß L, Reitinger C, Lux A (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 2713
Pages Range: 117-128
DOI: 10.1007/978-1-0716-3437-0_7
Human immune system mice, also referred to as humanized mice, are a major research tool for the in vivo study of human immune system function. Upon reconstitution with human hematopoietic stem cells, all major human leukocyte populations develop in immunodeficient mice and can be detected in peripheral blood as well as in lymphatic and nonlymphatic tissue. This includes human macrophages that are intrinsically difficult to study from humans due to their organ-resident nature. In the following chapter, we provide a detailed protocol for generation of human immune system mice. We suggest that these mice are a suitable model to study human macrophage function in vivo.
APA:
Voß, L., Reitinger, C., & Lux, A. (2024). Phenotyping of Macrophages in Human Immune System Mice. Methods in Molecular Biology, 2713, 117-128. https://doi.org/10.1007/978-1-0716-3437-0_7
MLA:
Voß, Leonie, Carmen Reitinger, and Anja Lux. "Phenotyping of Macrophages in Human Immune System Mice." Methods in Molecular Biology 2713 (2024): 117-128.
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