Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Ely S, Fernandez-Martín C, Fineberg S, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hardas A, Hart SN, Hartman J, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FuAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, Rapoport BL, Rau TT, Reis-Filho JS, Ribeiro JM, Rimm D, Salomon AV, Salto-Tellez M, Saltz J, Sayed S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, van Diest PJ, Verghese GE, Viale G, Vieth M, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Adams S, Bartlett JMS, Loibl S, Denkert C, Savas P, Loi S, Salgado R, Specht Stovgaard E, Akturk G, Bouchmaa N (2023)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Book Volume: 260

Pages Range: 514-532

Journal Issue: 5

DOI: 10.1002/path.6165

Abstract

Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.

Authors with CRIS profile

Involved external institutions

Karolinska Institute Sweden (SE) National Cancer Institute (NCI) United States (USA) (US) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Earle A. Chiles Research Institute at the Robert W. Franz Cancer Center United States (USA) (US) Emory University United States (USA) (US) Sunnybrook Health Sciences Centre Canada (CA) The Institute of Cancer Research (ICR) United Kingdom (GB) Vanderbilt University United States (USA) (US) University of the Frontier / Universidad de La Frontera (UFRO) Chile (CL) Weill Cornell Medicine United States (USA) (US) Praava Health Bangladesh (BD) University of London United Kingdom (GB) Bristol-Myers Squibb United States (USA) (US) University of British Columbia Canada (CA) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) Centre Jean-Perrin (UNICANCER) France (FR) New York University (NYU) United States (USA) (US) Hospital Clínico Universitario de Valencia Spain (ES) Mines ParisTech / École Nationale Supérieure des Mines de Paris (ENSMP) France (FR) Yale University United States (USA) (US) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) University College Dublin (UCD) Ireland (IE) Stavanger University Hospital Norway (NO) All India Institute of Medical Sciences Raipur (AIIMS) / अखिल भारतीय आयुर्विज्ञान संस्थान रायपुर India (IN) Institut Jules Bordet Belgium (BE) University of Washington United States (USA) (US) Matsuyama Shimin Hospital / 松山市民病院 Japan (JP) University College London Hospitals (UCLH) United Kingdom (GB) Manipal Hospitals India India (IN) Tehran University of Medical Sciences (TUMS) / دانشگاه علوم پزشکی تهران Iran, Islamic Republic of (IR) Federal University of Amazonas / Universidade Federal do Amazonas (UFAM) Brazil (BR) Hospital Universitário Getúlio Vargas (HUGV) Brazil (BR) University of Surrey United Kingdom (GB) Polytechnic University of Valencia / Universidad Politécnica de Valencia Spain (ES) GZA Ziekenhuizen Belgium (BE) King’s College London United Kingdom (GB) Albert Einstein College of Medicine United States (USA) (US) Institut Curie France (FR) Iwate Medical University Japan (JP) Tempus Labs United States (USA) (US) Massachusetts General Hospital United States (USA) (US) Stony Brook Medicine United States (USA) (US) Aakash Healthcare Super Speciality Hospital India (IN) Allergan Pharmaceuticals, Inc. United States (USA) (US) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT) University of Warwick United Kingdom (GB) Universitätsklinikum Heidelberg Germany (DE) Memorial Sloan Kettering Cancer Center United States (USA) (US) Georgia Institute of Technology United States (USA) (US) National Surgical Adjuvant Breast and Bowel Project Foundation (NSABP) United States (USA) (US) Mayo Clinic Hospital United States (USA) (US) ICGA Foundation India (IN) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset Sweden (SE) Peter MacCallum Cancer Centre Australia (AU) Iuliu Hațieganu University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Iuliu Hațieganu" (UMF Cluj) Romania (RO) Heinrich-Heine-Universität Düsseldorf Germany (DE) F. Hoffmann-La Roche Ltd Switzerland (CH) Université Mohammed VI Polytechnique (UM6P) Morocco (MA) Copenhagen University Hospital Denmark (DK) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) Philipps-Universität Marburg Germany (DE) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT) Fudan University / 复旦大学 China (CN) CellCarta Canada (CA) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) King Hussein Cancer Center (KHCC) / مركز الحسين للسرطان Jordan (JO) Hospital María Curie Argentina (AR) Institut Gustave-Roussy France (FR) Merck & Co., Inc. / Merck Sharp & Dohme Corp (MSD) United States (USA) (US) Genentech Inc. United States (USA) (US) University of Edinburgh United Kingdom (GB) Narayana Medical College & Hospital India (IN) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Kyoto University / 京都大学 Kyōto daigaku Japan (JP) Medical Oncology Centre of Rosebank South Africa (ZA) Centro Medico Nacional Siglo XXI Mexico (MX) Aga Khan University (AKU) / آغا خان یونیورسٹی‎ Pakistan (PK) The National University of Malaysia / Universiti Kebangsaan Malaysia (UKM) Malaysia (MY) CRUK Lung Cancer Centre of Excellence United Kingdom (GB) University of Birmingham United Kingdom (GB) University of Pennsylvania (UPenn) United States (USA) (US) Northwestern University United States (USA) (US) Technical University of Denmark / Danmarks Tekniske Universitet (DTU) Denmark (DK) GBG Forschungs GmbH (German Breast Group) Germany (DE) State University of New York at Albany (UNY Albany / UAlbany) United States (USA) (US) University of Texas MD Anderson Cancer Center United States (USA) (US) Mayo Clinic United States (USA) (US) Ziauddin University (ZU) Pakistan (PK) Sjællands Universitetshospital, Roskilde Denmark (DK) Guy's and St Thomas' (NHS Foundation Trust) United Kingdom (GB) Icahn School of Medicine at Mount Sinai United States (USA) (US) Ann & Robert H. Lurie Children's Hospital of Chicago United States (USA) (US) The University of Melbourne Australia (AU) Case Western Reserve University United States (USA) (US)

How to cite

APA:

Page, D.B., Broeckx, G., Jahangir, C.A., Verbandt, S., Gupta, R.R., Thagaard, J.,... Bouchmaa, N. (2023). Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 260(5), 514-532. https://doi.org/10.1002/path.6165

MLA:

Page, David B., et al. "Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 260.5 (2023): 514-532.

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