On the quantum description of irradiation dynamics in systems of biological relevance

Dinh PM, Bouässel du Bourg L, Gao CZ, Gu B, Lacombe L, McAllister M, Smyth M, Tribello G, Vincendon M, Kohanoff J, Reinhard PG, Sanche L, Suraud E (2016)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2016

Publisher: Springer International Publishing

Edited Volumes: Nanoscale Insights into Ion-Beam Cancer Therapy

Pages Range: 277–309

ISBN: 9783319430300

DOI: 10.1007/978-3-319-43030-0_8

Abstract

The two main products of ionizing radiation in biological tissues are electrons and radicals. The numerous secondary electrons are generated by ionisation in the molecules in the vicinity of DNA and are produced with a mean energy about 10 eV. These low-energy electrons can lead to DNA strand breaks via dissociative electron attachment and other mechanisms. The modelling of these phenomena requires, on the one hand, an explicit quantum description of the electrons of the target molecule (typically, a subunit of a DNA strand), and on the other hand, a realistic account of theDNAenvironment. This chapter reviews theoretical and computational approaches that have allowed us to study electron dynamics (excitation, ionization, transport and localization) in systems of biological interest.

Authors with CRIS profile

Paul-Gerhard Reinhard Naturwissenschaftliche Fakultät

Involved external institutions

Université Toulouse III - Paul Sabatier FR France (FR) Queen's University GB United Kingdom (GB) Université de Sherbrooke CA Canada (CA)

How to cite

APA:

Dinh, P.M., Bouässel du Bourg, L., Gao, C.Z., Gu, B., Lacombe, L., McAllister, M.,... Suraud, E. (2016). On the quantum description of irradiation dynamics in systems of biological relevance. In Andrey V. Solov’yov (Eds.), Nanoscale Insights into Ion-Beam Cancer Therapy. (pp. 277–309). Springer International Publishing.

MLA:

Dinh, P. M., et al. "On the quantum description of irradiation dynamics in systems of biological relevance." Nanoscale Insights into Ion-Beam Cancer Therapy. Ed. Andrey V. Solov’yov, Springer International Publishing, 2016. 277–309.

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