Type 2 Immunity Regulates Dermal White Adipose Tissue Function

Satzinger S, Willenborg S, Ding X, Klose CS, Radtke D, Vöhringer D, Eming SA (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Journal of Investigative Dermatology Elsevier

DOI: 10.1016/j.jid.2023.05.017

Abstract

Type 2 immune responses have been increasingly linked with tissue maintenance, regeneration, and metabolic homeostasis. The molecular basis of regulator and effector mechanisms of type 2 immunity in skin regeneration and homeostasis is still lacking. In this study, we analyzed the role of IL-4Rα signaling in the regeneration of diverse cellular compartments in the skin. Mutants with global IL-4Rα deficiency showed two major phenotypes: first, a pronounced atrophy of the interfollicular epidermis, and second, a significant increase in dermal white adipose tissue thickness in mice aged 3 weeks (postnatal day 21) compared with littermate controls. Notably, IL-4Rα deficiency decreased the activation of hormone-sensitive lipase, a rate-limiting step in lipolysis. Immunohistochemical and FACS analysis in IL-4/enhanced GFP reporter mice showed that IL-4 expression peaked on postnatal day 21 and that eosinophils are the predominant IL-4–expressing cells. Eosinophil-deficient mice recapitulated the lipolytic-defective dermal white adipose tissue phenotype of Il4ra-deficient mice, showing that eosinophils are necessary for dermal white adipose tissue lipolysis. Collectively, we provide mechanistic insights into the regulation of interfollicular epidermis and hormone-sensitive lipase–mediated lipolysis in dermal white adipose tissue in early life by IL-4Rα, and our findings show that eosinophils play a critical role in this process.

Authors with CRIS profile

Daniel Radtke Department of Infection Biology David Vöhringer Department of Infection Biology

Involved external institutions

Universität zu Köln DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Satzinger, S., Willenborg, S., Ding, X., Klose, C.S., Radtke, D., Vöhringer, D., & Eming, S.A. (2023). Type 2 Immunity Regulates Dermal White Adipose Tissue Function. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2023.05.017

MLA:

Satzinger, Sabrina, et al. "Type 2 Immunity Regulates Dermal White Adipose Tissue Function." Journal of Investigative Dermatology (2023).

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