Locoregional metastatic behavior in a complex mosaic of primary malignant tumors of the parotid gland

Varga R, Iro AK, Thimsen V, Sievert M, Agaimy A, Balk M, Rupp R, Grundtner P, Koch M, Iro H, Mantsopoulos K (2023)

Publication Type: Journal article

Publication year: 2023

Journal

American Journal of Otolaryngology WB Saunders

Book Volume: 44

Article Number: 103973

Journal Issue: 6

DOI: 10.1016/j.amjoto.2023.103973

Abstract

Background: The aim of the study was to investigate primary locoregional metastatic behavior in a large sample of various malignant tumors of the parotid gland with varying grades following surgical treatment consisting of complete parotidectomy and neck dissection. Methods: The records of all patients treated for primary malignant tumors of the parotid gland by means of complete parotidectomy and neck dissection between 2007 and 2022 were studied retrospectively. Results: 196 patients formed our study sample (98 females, 98 males). The mean age was 65.7 years (22–101 years). 92 cases presented with low-grade subtypes, 19 with intermediate-grade, and 85 with high-grade carcinomas. The locoregional lymphatic network had been invaded in a total of 66/196 cases (33.6 %). The intraparotid lymph nodes were positive in 54/196 cases (27.5 %) and the cervical lymph nodes in 41/196 cases (20.9 %). In 12 out of the 66 cases with a pN+ status, the neck had been invaded without involvement of the intraparotideal lymph nodes (18.2 %). Male patients tended to suffer from more aggressive carcinomas, and high-grade subtypes presented significantly more frequently as locally advanced tumors. Higher grading was significantly associated with the involvement of the parotid (p < 0.001) and cervical (p < 0.001) lymph nodes. Intermediate and low-grade cases presented similar behavior concerning tumorous invasion of the lymphatic network of the parotid gland (p = 0.522) and the neck (p = 0.467). Conclusion: The locoregional metastatic potential of parotid malignant tumors depends upon a variety of histopathologic factors, which have to be considered in the decision-making process concerning the management of locoregional lymph nodes.

Authors with CRIS profile

Regina Varga Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Vivian Thimsen Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Matti Sievert Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Robin Rupp Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Heinrich Iro Lehrstuhl für Hals-Nasen-Ohrenheilkunde Konstantinos Mantsopoulos Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik)

How to cite

APA:

Varga, R., Iro, A.K., Thimsen, V., Sievert, M., Agaimy, A., Balk, M.,... Mantsopoulos, K. (2023). Locoregional metastatic behavior in a complex mosaic of primary malignant tumors of the parotid gland. American Journal of Otolaryngology, 44(6). https://doi.org/10.1016/j.amjoto.2023.103973

MLA:

Varga, Regina, et al. "Locoregional metastatic behavior in a complex mosaic of primary malignant tumors of the parotid gland." American Journal of Otolaryngology 44.6 (2023).

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