Serum levels of the Th1 chemoattractant interferon-gamma-inducible protein (IP) 10 are elevated in patients with essential hypertension

Stumpf C, Auer C, Yilmaz A, Lewczuk P, Klinghammer L, Schneider M, Daniel W, Schmieder R, Garlichs C (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Hypertension Research Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 34

Pages Range: 484-488

Journal Issue: 4

DOI: 10.1038/hr.2010.258

Abstract

Growing evidence shows that inflammation has a pivotal role in the pathophysiology of essential hypertension (EH). Although it has been acknowledged that target organ damage involves an inflammatory response, most work has focused on the role of macrophages, but T lymphocytes have recently become the center of interest. The goal of our study was to evaluate the role of T-cell-specific cytokines in the pathogenesis of EH. The study examined 39 patients with EH (57.7±6.8 years, systolic blood pressure (SBP) 157.5±11.8 mm Hg, diastolic blood pressure 92.2±12.9 mm Hg, mean arterial pressure 113.9±12.6 mm Hg) and 30 healthy, normotensive controls (55.2±4.9 years). Blood was drawn from a peripheral vein, and serum levels of interferon-inducible protein (IP)-10 and interleukins (IL)-4,-7 and-13 were measured by a multiplexing assay. Hypertensive patients had significantly higher levels of IP-10, IL-4, IL-7 and IL-13 than control subjects. When the patients were classified into tertiles according to their serum IP-10 levels (T1: 41.2-9±4.1 pg ml^-1; T2: 103.4-1±62.5 pg ml 1; T3: 171.7-443.5 pgml 1), the patients classified into the highest tertile also had the highest blood pressure. In a correlation analysis, plasma IP-10 concentration was significantly associated with SBP (r0.59, P<0.001). Furthermore, hypertensives with microalbuminuria, an early sign of hypertensive target organ damage, had the highest IP-10 levels. A stepwise multivariate regression analysis revealed IP-10 as the strongest independent predictor of SBP (P<0.01). In conclusion, our study provides new insights into the pathophysiological mechanisms in EH linking inflammation and IP-10. However, these preliminary results need to be confirmed in larger trials. © 2011 The Japanese Society of Hypertension All rights reserved.

Authors with CRIS profile

Christian Stumpf Department of Medicine 2 – Cardiology and Angiology Claudia Auer Medizinische Fakultät Piotr Lewczuk Medizinische Fakultät Lutz Klinghammer Department of Medicine 2 – Cardiology and Angiology Markus Schneider Department of Medicine 4 – Nephrology and Hypertension Werner Daniel Medizinische Fakultät Roland Schmieder Professur für Innere Medizin (Nephrologie) Christoph Garlichs Medizinische Fakultät

Involved external institutions

Friedrich-Schiller-Universität Jena

Germany (DE)

How to cite

APA:

Stumpf, C., Auer, C., Yilmaz, A., Lewczuk, P., Klinghammer, L., Schneider, M.,... Garlichs, C. (2011). Serum levels of the Th1 chemoattractant interferon-gamma-inducible protein (IP) 10 are elevated in patients with essential hypertension. Hypertension Research, 34(4), 484-488. https://doi.org/10.1038/hr.2010.258

MLA:

Stumpf, Christian, et al. "Serum levels of the Th1 chemoattractant interferon-gamma-inducible protein (IP) 10 are elevated in patients with essential hypertension." Hypertension Research 34.4 (2011): 484-488.

BibTeX: Download