Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele

Raaz-Schrauder D, Ekici AB, Munoz LE, Klinghammer L, Voll RE, Leusen JH, Van De Winkel JG, Reis A, Schett G, Garlichs C, Herrmann M (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Autoimmunity Informa Healthcare

Book Volume: 45

Pages Range: 556-564

Journal Issue: 7

DOI: 10.3109/08916934.2012.682665

Abstract

Patients with Systemic Lupus Erythematosus (SLE) carry an increased risk for the development of coronary artery disease (CAD). The R131 allele of the Fc gamma receptor IIa (FcγRIIa) is associated with SLE incidence and disease severity but also with CAD. Compared to stable angina pectoris (SAP) the unstable angina (UAP), as a manifestation of destabilizing CAD, is associated with increased risk of persistent instability, myocardial infarction, and death. Identification of clinically relevant determinants for unstable angina promises reduction of UAP-associated mortality in patients with SLE. We conducted a clinical study among 553 consecutive patients with stable angina pectoris (n 330) and unstable angina pectoris (n 223). All patients were genotyped for a frequent functional variant at position 131 of the mature FcγRIIa. UAP, but not SAP was significantly associated with the R/R131 genotype (P < 0.001). In troponin-negative patients with angina carrying the R/R131 genotype the odds ratio for suffering from UAP was 4.02 (95% confidence interval, 2.526.41) compared to those with non-R/R131 genotypes. In a multivariable analysis, the R/R131 genotype independently predicted the risk for development of UAP in a model adjusted for classical atherogenic risk factors. Our data imply that risk stratification of SLE- and other high risk patients with troponin-negative angina could be significantly improved by FcγRIIa genotyping. © Informa UK, Ltd.

Authors with CRIS profile

Dorette Raaz-Schrauder Medizinische Fakultät Arif Bülent Ekici Lehrstuhl für Humangenetik Luis Munoz Becerra Department of Medicine 3 – Rheumatology and Immunology Lutz Klinghammer Department of Medicine 2 – Cardiology and Angiology André Wiesmann da Silva Reis Lehrstuhl für Humangenetik Georg Schett Lehrstuhl für Innere Medizin III Christoph Garlichs Medizinische Fakultät Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Raaz-Schrauder, D., Ekici, A.B., Munoz, L.E., Klinghammer, L., Voll, R.E., Leusen, J.H.,... Herrmann, M. (2012). Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele. Autoimmunity, 45(7), 556-564. https://doi.org/10.3109/08916934.2012.682665

MLA:

Raaz-Schrauder, Dorette, et al. "Patients with unstable angina pectoris show an increased frequency of the Fc gamma RIIa R131 allele." Autoimmunity 45.7 (2012): 556-564.

BibTeX: Download