Fertilität, Kontrazeption und Teratogenität bei Immuncheckpointblockade

Hassel JC, Berking C (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Die Dermatologie Springer

Book Volume: 74

Pages Range: 501-504

Journal Issue: 7

DOI: 10.1007/s00105-023-05165-y

Abstract

Background: Immune checkpoint inhibitors (ICI) are now being used in a number of dermato-oncological indications. In particular, the approval for adjuvant therapy of high-risk stage IIB/C and III melanoma means that more patients of fertile age receive ICI. Objectives: This raises the question of how ICIs affect male and female fertility and whether they are teratogenic. Materials and methods: Compilation of current data from the summary of product characteristics (SmPCs) and by literature search (PubMed). Results: Immune-related adverse events of ICI can impair fertility in the acute stage, and especially in the case of endocrine side effects, also in the long term. These include hypothyroidism, as well as adrenal and pituitary insufficiency. However, fertility can usually be restored with hormone replacement. Direct autoimmune effects on the reproductive organs are probably very rare, although immune-related orchitis has been described. Reliable contraception should be used in women of childbearing age. Pregnant women should only receive ICI in urgent exceptional cases, because the miscarriage rate is probably significantly increased. Conclusions: Unfortunately, the current data on patient counselling is still very sparse. Scientific studies on the influence of ICI on fertility and teratogenicity are urgently needed.

Authors with CRIS profile

Carola Berking Lehrstuhl für Haut- und Geschlechtskrankheiten

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE)

How to cite

APA:

Hassel, J.C., & Berking, C. (2023). Fertilität, Kontrazeption und Teratogenität bei Immuncheckpointblockade. Die Dermatologie, 74(7), 501-504. https://doi.org/10.1007/s00105-023-05165-y

MLA:

Hassel, Jessica C., and Carola Berking. "Fertilität, Kontrazeption und Teratogenität bei Immuncheckpointblockade." Die Dermatologie 74.7 (2023): 501-504.

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