Rühle J, Klemt I, Mokhir A (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 28
Article Number: 4204
Journal Issue: 10
DOI: 10.3390/molecules28104204
RNA interference (RNAi) using small interfering RNAs (siRNAs) is a powerful tool to target any protein of interest and is becoming more suitable for in vivo applications due to recent developments in RNA delivery systems. To exploit RNAi for cancer treatment, it is desirable to increase its selectivity, e.g., by a prodrug approach to activate the siRNAs upon external triggering, e.g., by using light. Red light is especially well suited for in vivo applications due to its low toxicity and higher tissue penetration. Known molecular (not nanoparticle-based) red-light-activatable siRNA prodrugs rely on singlet oxygen (1O
APA:
Rühle, J., Klemt, I., & Mokhir, A. (2023). Triggering RNA Interference by Photoreduction under Red Light Irradiation. Molecules, 28(10). https://doi.org/10.3390/molecules28104204
MLA:
Rühle, Jennifer, Insa Klemt, and Andriy Mokhir. "Triggering RNA Interference by Photoreduction under Red Light Irradiation." Molecules 28.10 (2023).
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