Neutrophil Extracellular Trap-Borne Elastase Prevents Inflammatory Relapse in Intercritical Gout

Liu L, Shan L, Wang H, Schauer C, Schoen J, Zhu L, Lu C, Wang Z, Xue Y, Wu H, Herrmann M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Arthritis and Rheumatology Wiley

DOI: 10.1002/art.42431

Abstract

Objective. Gout flares that occur during urate-lowering therapy (ULT) are typically related to the shrinkage of tophi due to aggregated neutrophil extracellular traps (NETs) that have captured monosodium urate crystals in the tissues. The present study was undertaken to analyze the blocking effect of alpha(1)-antitrypsin on neutrophil elastase, and it was found that alpha(1)-antitrypsin induced rapid inflammation in the presence of unstable tophi.

Authors with CRIS profile

Han Wang Medizinische Fakultät Christine Schauer Department of Medicine 3 – Rheumatology and Immunology Janina Schoen Department of Medicine 3 – Rheumatology and Immunology Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Zhejiang University CN China (CN) Fudan University / 复旦大学 CN China (CN)

How to cite

APA:

Liu, L., Shan, L., Wang, H., Schauer, C., Schoen, J., Zhu, L.,... Herrmann, M. (2023). Neutrophil Extracellular Trap-Borne Elastase Prevents Inflammatory Relapse in Intercritical Gout. Arthritis and Rheumatology. https://doi.org/10.1002/art.42431

MLA:

Liu, Lei, et al. "Neutrophil Extracellular Trap-Borne Elastase Prevents Inflammatory Relapse in Intercritical Gout." Arthritis and Rheumatology (2023).

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