Datzmann T, Münz F, Hoffmann A, Moehrke E, Binzenhöfer M, Gröger M, Kapapa T, Mathieu R, Mayer S, Zink F, Gässler H, Wolfschmitt EM, Hogg M, Merz T, Calzia E, Radermacher P, Messerer DAC (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 14
Article Number: 1123196
DOI: 10.3389/fimmu.2023.1123196
Severe physical injuries and associated traumatic brain injury and/or hemorrhagic shock (HS) remain leading causes of death worldwide, aggravated by accompanying extensive inflammation. Retrospective clinical data indicated an association between mild hyperoxemia and improved survival and outcome. However, corresponding prospective clinical data, including long-term resuscutation, are scarce. Therefore, the present study explored the effect of mild hyperoxemia for 24 hours in a prospective randomized controlled trial in a long-term resuscitated model of combined acute subdural hematoma (ASDH) and HS. ASDH was induced by injecting 0.1 ml × kg−1 autologous blood into the subdural space and HS was triggered by passive removal of blood. After 2 hours, the animals received full resuscitation, including retransfusion of the shed blood and vasopressor support. During the first 24 hours, the animals underwent targeted hyperoxemia (P
APA:
Datzmann, T., Münz, F., Hoffmann, A., Moehrke, E., Binzenhöfer, M., Gröger, M.,... Messerer, D.A.C. (2023). An exploratory study investigating the effect of targeted hyperoxemia in a randomized controlled trial in a long-term resuscitated model of combined acute subdural hematoma and hemorrhagic shock in cardiovascular healthy pigs. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1123196
MLA:
Datzmann, Thomas, et al. "An exploratory study investigating the effect of targeted hyperoxemia in a randomized controlled trial in a long-term resuscitated model of combined acute subdural hematoma and hemorrhagic shock in cardiovascular healthy pigs." Frontiers in Immunology 14 (2023).
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