Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy
Bulaeva OA, Abramicheva PA, Balakina TA, Smirnova OV (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 162
Pages Range: 611-614
Journal Issue: 5
DOI: 10.1007/s10517-017-3669-2
Abstract
We studied possible involvement of prolactin in the regulation of bicarbonate biodynamics using female rat model of cholestasis of pregnancy induced by transplantation of the donor pituitary under the renal capsule of a recipient (hyperprolactinemia) and bile duct ligation (cholestasis). The concentration of bicarbonates in the bile and blood, their excretion, clearance, and reabsorption, as well as glomerular filtration rate and excretion of sodium ions were assessed. It was found that the main effect of prolactin was directed to the kidney-regulated pool of bicarbonates and consisted in stimulation of their clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration. Parallel influence of prolactin on the clearance of bicarbonates and sodium ions was observed.
Involved external institutions
Russian Federation (RU)How to cite
APA:
Bulaeva, O.A., Abramicheva, P.A., Balakina, T.A., & Smirnova, O.V. (2017). Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy. Bulletin of Experimental Biology and Medicine, 162(5), 611-614. https://dx.doi.org/10.1007/s10517-017-3669-2
MLA:
Bulaeva, O. A., et al. "Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy." Bulletin of Experimental Biology and Medicine 162.5 (2017): 611-614.
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