Role of Na+/K+-ATPase in natriuretic effect of prolactin in a model of cholestasis of pregnancy
Abramicheva PA, Balakina TA, Bulaeva OA, Guseva AA, Lopina OD, Smirnova OV (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 82
Pages Range: 632-641
Journal Issue: 5
DOI: 10.1134/S000629791705011X
Abstract
Participation of Na+/K+-ATPase in the natriuretic effect of prolactin in a cholestasis of pregnancy model was investigated. The Na+/K+-ATPase activity in rat kidney medulla, where active sodium reabsorption occurs, decreased in the model of cholestasis of pregnancy and other hyperprolactinemia types compared with intact animals. This effect was not connected with the protein level of α1- and β-subunits of Na+/K+-ATPase measured by Western blotting in the kidney medulla. Decrease in Na+/K+-ATPase activity in the kidney cortex was not significant, as well as decrease in the quantity of mRNA and proteins of the α1- and β-subunits of Na+/K+-ATPase. There were no correlations between the Na+/K+-ATPase activity and sodium clearance, although sodium clearance increased significantly in the model of cholestasis of pregnancy and other hyperprolactinemia groups under conditions of stable glomerular filtration rate measured by creatinine clearance. We conclude that the Na+/K+-ATPase is not the only mediator of the natriuretic effect of prolactin in the model of cholesta- sis of pregnancy.
Involved external institutions
Russian Federation (RU)How to cite
APA:
Abramicheva, P.A., Balakina, T.A., Bulaeva, O.A., Guseva, A.A., Lopina, O.D., & Smirnova, O.V. (2017). Role of Na+/K+-ATPase in natriuretic effect of prolactin in a model of cholestasis of pregnancy. Biochemistry-Moscow, 82(5), 632-641. https://dx.doi.org/10.1134/S000629791705011X
MLA:
Abramicheva, P. A., et al. "Role of Na+/K+-ATPase in natriuretic effect of prolactin in a model of cholestasis of pregnancy." Biochemistry-Moscow 82.5 (2017): 632-641.
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