A Water-Soluble Mn(CO)3-Based and Non-Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells

Mede R, Hoffmann P, Klein M, Goerls H, Schmitt M, Neugebauer U, Gessner G, Heinemann SH, Popp J, Westerhausen M (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Zeitschrift für Anorganische und Allgemeine Chemie Wiley

Book Volume: 643

Pages Range: 2057-2062

Journal Issue: 23

DOI: 10.1002/zaac.201700349

Abstract

The photoCORMs [Mn(CO)3(L)]Br with the tridentate ligands L1 = S[(CH2)2NH2]2 (1) (CORM-EDE3) and L2 = cyclo-S[(CH2)2NH(CH2-)]2 (2) (CORM-EDE4) are non-toxic and release all CO ligands upon irradiation. Reduction of the hydrophilicity of the cation by L2 (thia-4,7-diazacyclononane) enables accumulation of the resulting water-soluble CORM-EDE4 as well as administration of CO inside of cells.

Involved external institutions

Leibniz-Institut für Photonische Technologien e.V. DE Germany (DE) Universitätsklinikum Jena DE Germany (DE) Friedrich-Schiller-Universität Jena DE Germany (DE)

How to cite

APA:

Mede, R., Hoffmann, P., Klein, M., Goerls, H., Schmitt, M., Neugebauer, U.,... Westerhausen, M. (2017). A Water-Soluble Mn(CO)3-Based and Non-Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells. Zeitschrift für Anorganische und Allgemeine Chemie, 643(23), 2057-2062. https://doi.org/10.1002/zaac.201700349

MLA:

Mede, Ralf, et al. "A Water-Soluble Mn(CO)3-Based and Non-Toxic PhotoCORM for Administration of Carbon Monoxide Inside of Cells." Zeitschrift für Anorganische und Allgemeine Chemie 643.23 (2017): 2057-2062.

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