Light-responsive paper strips as CO-releasing material with a colourimetric response

Reddy UG, Liu J, Hoffmann P, Steinmetzer J, Goerls H, Kupfer S, Askes SHC, Neugebauer U, Gräfe S, Schiller A (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Chemical Science Royal Society of Chemistry

Book Volume: 8

Pages Range: 6555-6560

Journal Issue: 9

DOI: 10.1039/c7sc01692a

Abstract

Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(i) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC50 ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye.

Involved external institutions

Friedrich-Schiller-Universität Jena

Germany (DE) Leibniz-Institut für Photonische Technologien e.V.

Germany (DE)

How to cite

APA:

Reddy, U.G., Liu, J., Hoffmann, P., Steinmetzer, J., Goerls, H., Kupfer, S.,... Schiller, A. (2017). Light-responsive paper strips as CO-releasing material with a colourimetric response. Chemical Science, 8(9), 6555-6560. https://doi.org/10.1039/c7sc01692a

MLA:

Reddy, Upendar G., et al. "Light-responsive paper strips as CO-releasing material with a colourimetric response." Chemical Science 8.9 (2017): 6555-6560.

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