CaZnOS:Nd3+ Emits Tissue-Penetrating near-Infrared Light upon Force Loading

Li L, Wondraczek L, Li L, Zhang Y, Zhu Y, Peng M, Mao C (2018)

Publication Type: Journal article

Publication year: 2018

Journal

ACS Applied Materials and Interfaces American Chemical Society

Book Volume: 10

Pages Range: 14509-14516

Journal Issue: 17

DOI: 10.1021/acsami.8b02530

Abstract

Mechanoluminescent (ML) materials are mechano-optical converters that can emit light under an external mechanical stimulus. All the existing ML materials can only emit light from near ultraviolet to red, which is outside the near-infrared (NIR) windows desired for biomechanical imaging. No studies have been done on doping rare earth (RE) ions with photoluminescence (PL) in the NIR region into a compound to form a ML material that emits NIR light in response to an external force. Here, we show that doping RE ions with a NIR PL into an inorganic compound does not usually result in the formation of a NIR ML material, which can only be achieved in the combination of Nd3+ ions and a CaZnOS compound among the combinations we studied. The newly discovered NIR ML material (CaZnOS:Nd3+) is biocompatible and can efficiently convert mechanical stress into NIR light over the first and second tissue-penetrating bioimaging window. Its NIR ML emission appeared at a very low force threshold (even when the material was shaken slightly), increased sensitively and linearly with the increase in the force (up to >5 kN), and could penetrate the tissue as deep as >22 mm to enable biomechanical detection. Such a force-responsive behavior is highly reproducible. Hence, CaZnOS:Nd3+ is a new potential ultrasensitive biomechanical probe and expands the ML application horizons into in vivo bioimaging.

Authors with CRIS profile

Lothar Wondraczek

Involved external institutions

South China University of Technology (SCUT) / 华南理工大学 CN China (CN) Friedrich-Schiller-Universität Jena DE Germany (DE) General Hospital of Guangzhou Military Command / 广州军区广州总医院 CN China (CN) University of Oklahoma US United States (USA) (US)

How to cite

APA:

Li, L., Wondraczek, L., Li, L., Zhang, Y., Zhu, Y., Peng, M., & Mao, C. (2018). CaZnOS:Nd3+ Emits Tissue-Penetrating near-Infrared Light upon Force Loading. ACS Applied Materials and Interfaces, 10(17), 14509-14516. https://doi.org/10.1021/acsami.8b02530

MLA:

Li, Lejing, et al. "CaZnOS:Nd3+ Emits Tissue-Penetrating near-Infrared Light upon Force Loading." ACS Applied Materials and Interfaces 10.17 (2018): 14509-14516.

BibTeX: Download