Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy
Abramicheva PA, Kostenko YB, Balakina TA, Smirnova OV (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 168
Pages Range: 219-223
Journal Issue: 2
DOI: 10.1007/s10517-019-04678-8
Abstract
We analyzed the expression of molecular targets of natriuretic action of prolactin in different layers of the kidney in the rat model of cholestasis of pregnancy. Sodium bicarbonate cotransporter NBCe1 was most sensitive to the conditions of cholestasis and cholestasis of pregnancy: the expression NBCe1 mRNA and protein in the renal outer medulla decreased in comparison with the normal. All forms of cholestasis affected the mRNA expression of sodium-potassium chloride co-transporter NCC, α-subunit of the ENaCα epithelial sodium channel, and Nedd4-2 ubiquitin ligase in different layers of the kidney. The obtained data suggest that prolactin provides fine tuning of various sodium transporters in different parts of the nephron under pathological conditions.
Involved external institutions
Russian Federation (RU)How to cite
APA:
Abramicheva, P.A., Kostenko, Y.B., Balakina, T.A., & Smirnova, O.V. (2019). Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy. Bulletin of Experimental Biology and Medicine, 168(2), 219-223. https://dx.doi.org/10.1007/s10517-019-04678-8
MLA:
Abramicheva, P. A., et al. "Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy." Bulletin of Experimental Biology and Medicine 168.2 (2019): 219-223.
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