New approach of staging and grading in bladder cancer with optical coherence tomography and Raman spectroscopy

Bovenkamp D, Sentosa R, Rank E, Erkkilae MT, Placzek F, Puels J, Drexler W, Leitgeb RA, Garstka N, Shariat SF, Stiebing C, Schie IW, Popp J, Andreana M, Unterhuber A (2019)

Publication Type: Conference contribution

Publication year: 2019

Publisher: OSA - The Optical Society

Book Volume: Part F142-ECBO 2019

Conference Proceedings Title: Optics InfoBase Conference Papers

Event location: Munich, NLD

ISBN: 9781557528209

DOI: 10.1117/12.2526751

Abstract

Our study targets improved and accelerated diagnostics of bladder cancer with optical coherence tomography (OCT) and Raman spectroscopy (RS) ex vivo. OCT provides structural information on the penetration depth of the lesion, whereas RS complements this information with molecular characteristics regarding the likelihood of growth and spreading. Hence, the diagnostic findings include the determination of stage and grade of a tumor. The bladder specimens were scanned with OCT to detect suspicious lesions. Thereby, OCT was used as a red-flag technology to examine the bladder wall for abnormal tissue. Malignant bladder wall could be discriminated from healthy tissue. Upon identification of a cancerous lesion, RS added diagnostic information with molecular characteristics of the tumor regarding the grade. Texture analysis of OCT tomograms followed by k-nearest neighbour classification determined the stage of the lesion. Principal component analysis (PCA) of Raman spectra allowed for dimension reduction which was also fed into a k-nearest neighbour classifier allowing for classification of low-grade and high-grade tumors. We obtained an accuracy of 71% and 93% for staging and grading, respectively.

Involved external institutions

Medizinische Universität Wien AT Austria (AT) Leibniz-Institut für Photonische Technologien e.V. DE Germany (DE)

How to cite

APA:

Bovenkamp, D., Sentosa, R., Rank, E., Erkkilae, M.T., Placzek, F., Puels, J.,... Unterhuber, A. (2019). New approach of staging and grading in bladder cancer with optical coherence tomography and Raman spectroscopy. In Optics InfoBase Conference Papers. Munich, NLD: OSA - The Optical Society.

MLA:

Bovenkamp, Daniela, et al. "New approach of staging and grading in bladder cancer with optical coherence tomography and Raman spectroscopy." Proceedings of the European Conference on Biomedical Optics, ECBO_2019, Munich, NLD OSA - The Optical Society, 2019.

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