Combination of Spontaneous and Coherent Raman Scattering Approaches with Other Spectroscopic Modalities for Molecular Multi-contrast Cancer Diagnosis
Krafft C, Popp J (2020)
Publication Type: Authored book
Publication year: 2020
Publisher: Springer International Publishing
ISBN: 9783030445942
DOI: 10.1007/978-3-030-44594-2_9
Abstract
Raman spectroscopy is a powerful bioanalytical method with high molecular specificity. The relatively low sensitivity of spontaneous Raman scattering can be overcome by signal enhancement effects such as surface enhanced Raman scattering and coherent Raman scattering, which is the collective term for coherent anti-Stokes Raman scattering and stimulated Raman scattering. Applications of Raman-based approaches for cancer diagnostics are summarized in the first part of the chapter. In the second part, complementary optical methods including autofluorescence, optical coherence tomography, second harmonic generation, and two-photon excited fluorescence were combined with Raman scattering as multi-contrast modalities. After training of multivariate chemometric classification models, Raman spectroscopy with or without other modalities has been used for pathological screening of cancer cells and tissues under ex vivo and in vivo conditions. Each modality is briefly introduced and typical examples are described.
Involved external institutions
Germany (DE)How to cite
APA:
Krafft, C., & Popp, J. (2020). Combination of Spontaneous and Coherent Raman Scattering Approaches with Other Spectroscopic Modalities for Molecular Multi-contrast Cancer Diagnosis. Springer International Publishing.
MLA:
Krafft, Christoph, and Jürgen Popp. Combination of Spontaneous and Coherent Raman Scattering Approaches with Other Spectroscopic Modalities for Molecular Multi-contrast Cancer Diagnosis. Springer International Publishing, 2020.
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