INFLUENCE OF GENDER, AGE AND METABOLIC FACTORS ON THE COURSE OF ARTERIAL HYPERTENSION IN PATIENTS WITH METABOLIC SYNDROME
Smirnova OV, Moskalenko OL (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 13
Pages Range: 41-60
Journal Issue: 5
DOI: 10.12731/2658-6649-2021-13-5-41-60
Abstract
According to the World Health Organization, more than 2.1 billion adults are overweight, while about 600 million are obese. Arterial hypertension is a component of the complete metabolic syndrome, its severity, the possibility of effective correction depends on the severity of metabolic disorders in the patient. The aim of our study was to study age, sex and metabolic parameters affecting the course of AH in MS in order to optimize therapy for patients with MS. Material and methods. The study included 316 patients with hypertension and metabolic syndrome aged 35 to 65 years. The average age of the patients was 51.8 ± 6.4 years. In total, 154 (48.73%) women and 162 (51.27%) men were examined. The patients were divided into three age groups: group 1 – patients aged 35-44 years, group 2 – from 45 to 54 years old, group 3 – from 55 to 65 years old. Clinical examination of patients included a clinical-anamnestic method (collection of complaints and anamnesis, examination) and work with medical records. The diagnosis of metabolic syndrome was verified based on the recommendations of the All-Russian Scientific Society of Cardiology (VNOK, 2009) if the patient had one main and at least two additional criteria. The main criterion for MS was the “central” (abdominal) type of obesity; additional signs – arterial hypertension; increased TG levels; a decrease in the level of HDL cholesterol; an increase in the level of LDL cholesterol; an increase in fasting plasma glucose; impaired glucose tolerance. For statistical processing of the research results, the Statistica for «Windows 10.0» software package was used. Results. The development of hypertension in different age groups depends on a combination of various factors that are interrelated with age-related changes in the cardiovascular system and metabolic parameters, which in general characterizes the features of its clinical course. MS itself has a significant impact on the development of hypertension. Conclusion. The comorbidity of obesity and the development of severe hypertension was revealed: there is an increase in the severity of hypertension with an increase in the degree of obesity. Age and obesity are both predictors of severe hypertension in MS. According to the predictive model, the following factors: male gender, with increasing age and degree of obesity, increases the likelihood of developing severe hypertension in MS. A comprehensive analysis of the total significance of risk factors, symptoms of target organ damage, taking into account age and gender factors, will make it possible to verify the individual variant of hypertension in MS, which will optimize the therapy of such patients and ensure a decrease in cardiovascular risk.
Involved external institutions
Russian Federation (RU)How to cite
APA:
Smirnova, O.V., & Moskalenko, O.L. (2021). INFLUENCE OF GENDER, AGE AND METABOLIC FACTORS ON THE COURSE OF ARTERIAL HYPERTENSION IN PATIENTS WITH METABOLIC SYNDROME. Siberian Journal of Life Sciences and Agriculture, 13(5), 41-60. https://dx.doi.org/10.12731/2658-6649-2021-13-5-41-60
MLA:
Smirnova, Olga V., and Olga L. Moskalenko. "INFLUENCE OF GENDER, AGE AND METABOLIC FACTORS ON THE COURSE OF ARTERIAL HYPERTENSION IN PATIENTS WITH METABOLIC SYNDROME." Siberian Journal of Life Sciences and Agriculture 13.5 (2021): 41-60.
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