Combined fiber probe for fluorescence lifetime and Raman spectroscopy

Dochow S, Ma D, Latka I, Bocklitz T, Hartl B, Bec J, Fatakdawala H, Marple E, Urmey K, Wachsmann-Hogiu S, Schmitt M, Marcu L, Popp J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Analytical and Bioanalytical Chemistry Springer

Book Volume: 407

Journal Issue: 27

DOI: 10.1007/s00216-015-8800-5

Abstract

In this contribution we present a dual modality fiber optic probe combining fluorescence lifetime imaging (FLIm) and Raman spectroscopy for in vivo endoscopic applications. The presented multi-spectroscopy probe enables efficient excitation and collection of fluorescence lifetime signals for FLIm in the UV/visible wavelength region, as well as of Raman spectra in the near-IR for simultaneous Raman/FLIm imaging. The probe was characterized in terms of its lateral resolution and distance dependency of the Raman and FLIm signals. In addition, the feasibility of the probe for in vivo FLIm and Raman spectral characterization of tissue was demonstrated. [Figure not available: see fulltext.]

Involved external institutions

Friedrich-Schiller-Universität Jena DE Germany (DE) University of California Davis (UCDAVIS) US United States (USA) (US) EmVision LLC US United States (USA) (US)

How to cite

APA:

Dochow, S., Ma, D., Latka, I., Bocklitz, T., Hartl, B., Bec, J.,... Popp, J. (2015). Combined fiber probe for fluorescence lifetime and Raman spectroscopy. Analytical and Bioanalytical Chemistry, 407(27). https://doi.org/10.1007/s00216-015-8800-5

MLA:

Dochow, Sebastian, et al. "Combined fiber probe for fluorescence lifetime and Raman spectroscopy." Analytical and Bioanalytical Chemistry 407.27 (2015).

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