Pathophysiological disorders in iron metabolism in the development of obesity and metabolic syndrome

Smirnova OV, Moskalenko OL, Kasparov EV, Kasparova IE (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Meditsinskiy sovet REMEDIUM GROUP Ltd.

Book Volume: 2022

Pages Range: 264-272

Journal Issue: 6

DOI: 10.21518/2079-701X-2022-16-6-264-272

Abstract

Obesity and metabolic syndrome are one of the major public health problems in the 21st century due to their prevalence. Nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, arterial hypertension, chronic inflammation and anemia are non-communicable diseases accompanying obesity. With obesity, there is a violation of iron metabolism, iron deficiency, which further contributes to the development of metabolic disorders. Iron is the second most abundant metal on Earth, and its bioavailability is reduced due to the formation of insoluble oxides, while iron deficiency is the most common nutritional disorder. Iron metabolism in the body is associated with the formation of reactive oxygen species involved in lipid peroxi dation processes. Iron metabolism in the human body is regulated at all levels; dysregulation of any stage of metabolism can lead to iron deficiency and the development of anemia associated with obesity. This review article summarizes data on molecular and cellular abnormalities in iron metabolism in obesity and metabolic syndrome. The aim of our study was to study, according to the literature, pathophysiological disorders in iron metabolism in the development of obesity and metabolic syndrome. In the future, more research is required to study iron metabolism in obesity with the aim of their preventive and therapeutic effects. The role of oxidative stress in impaired iron metabolism in obesity has not been fully studied, while iron deficiency enhances lipid peroxidation processes in antioxidant deficiency. Under these conditions, oxidative stress can damage cells and destroy red blood cells. The question arises whether the restoration of iron homeostasis in obesity can improve metabolic, inflammatory disorders and reduce the manifestation of oxidative stress, becoming a new innovative approach to the treatment of concomitant metabolic diseases associated with obesity.

Involved external institutions

Research Institute of Medical Problems of the North (RAMS) / Научно-исследовательский институт медицинских проблем Севера RU Russian Federation (RU)

How to cite

APA:

Smirnova, O.V., Moskalenko, O.L., Kasparov, E.V., & Kasparova, I.E. (2022). Pathophysiological disorders in iron metabolism in the development of obesity and metabolic syndrome. Meditsinskiy sovet, 2022(6), 264-272. https://dx.doi.org/10.21518/2079-701X-2022-16-6-264-272

MLA:

Smirnova, Olga V., et al. "Pathophysiological disorders in iron metabolism in the development of obesity and metabolic syndrome." Meditsinskiy sovet 2022.6 (2022): 264-272.

BibTeX: Download