The role of claudin-6 in chromophobe renal cell carcinoma

Erlmeier F, Zschäbitz S, Mikuteit M, Autenrieth M, Weichert W, Hartmann A, Steffens S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Histology and Histopathology Universidad de Murcia

Book Volume: 38

Pages Range: 403-407

Journal Issue: 4

DOI: 10.14670/HH-18-520

Abstract

BACKGROUND: The prognostic value of Claudin-6 (CLDN6) in non clear cell renal cell carcinoma (RCC) is still unclear. AIM: To evaluate the prognostic impact of CLDN6 expression in a large cohort of chromophobe RCC (chRCC). MATERIAL AND METHODS: Patients who underwent renal surgery due to chRCC were recruited. Clinical data were retrospectively evaluated. Tumor specimens were analyzed for CLDN6 expression by immunohistochemistry. RESULTS: 81 chRCC patients were eligible for analysis, thereof 10 (12.3%) patients were positive for CLDN6. No significant associations were found for CLDN6 expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in overall survival (OS) for patients with CLDN6⁻ compared to CLDN6⁺ tumors (87.0% versus 62.5%; p=0.174). CONCLUSION: In chRCC CLDN6 expression is not associated with parameters of aggressiveness or survival. Due to the rare incidence of chRCC further studies with larger cohorts are warranted.

Authors with CRIS profile

Franziska Erlmeier Institute of Pathology Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Additional Organisation(s)

FAU Profilzentrum Licht.Materie.Quantentechnologien (FAU LMQ)

Involved external institutions

Universitätsklinikum Heidelberg DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Erlmeier, F., Zschäbitz, S., Mikuteit, M., Autenrieth, M., Weichert, W., Hartmann, A., & Steffens, S. (2023). The role of claudin-6 in chromophobe renal cell carcinoma. Histology and Histopathology, 38(4), 403-407. https://doi.org/10.14670/HH-18-520

MLA:

Erlmeier, Franziska, et al. "The role of claudin-6 in chromophobe renal cell carcinoma." Histology and Histopathology 38.4 (2023): 403-407.

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