New Insights into Endothelin Signaling and Its Diverse Roles in the Retina
Schmitt SI, Bielmeier CB, Braunger BM (2019)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2019
Journal
Publisher: Springer
Series: Advances in Experimental Medicine and Biology
Book Volume: 1185
Pages Range: 519-523
DOI: 10.1007/978-3-030-27378-1_85
Abstract
The vasoactive peptide endothelin is an effective regulator of blood pressure and vascular homeostasis. In addition, the dysregulation of the endothelin signaling pathway is discussed to contribute to ocular diseases like glaucoma or diabetic retinopathy. Furthermore, our workgroup and others showed a protective effect of endothelin 2 for the survival of photoreceptors. In this study, we analyzed mRNA expression levels of the endothelin signaling family in wild-type mice after a puncture of the eye, intravitreal PBS injections, or light-induced photoreceptor degeneration. We observed elevated endothelin receptor a (Eta), endothelin receptor b (Etb), endothelin 1(Et1), and endothelin 2 (Et2) levels, while endothelin 3 (Et3) mRNA levels were not significantly altered. Our findings indicate an important role of the endothelin signaling pathway in response to ocular trauma or disease. These findings make endothelin signaling a promising target to attenuate retinal degeneration.
Involved external institutions
Germany (DE)How to cite
APA:
Schmitt, S.I., Bielmeier, C.B., & Braunger, B.M. (2019). New Insights into Endothelin Signaling and Its Diverse Roles in the Retina. In (pp. 519-523). Springer.
MLA:
Schmitt, Sabrina I., Christina B. Bielmeier, and Barbara M. Braunger. "New Insights into Endothelin Signaling and Its Diverse Roles in the Retina." Springer, 2019. 519-523.
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