The immune system's contribution to the clinical efficacy of EGFR antagonist treatment

Macdonald F, Zaiss DMW (2017)


Publication Type: Journal article, Review article

Publication year: 2017

Journal

Book Volume: 8

Article Number: 575

Journal Issue: AUG

DOI: 10.3389/fphar.2017.00575

Abstract

Epidermal Growth Factor Receptor (EGFR) antagonists were one of the first anti-cancer treatments developed targeting a Receptor Tyrosine Kinase. However, the underlying mode of action of how EGFR antagonist application can explain its clinical efficacy in different types of cancers remains largely unresolved. Numerous findings have suggested that a substantial portion of the effects attributed to EGFR antagonist treatment might not be based on direct influence on the tumor itself. Instead it may be based on indirect effects, potentially mediated via the immune system. In this review the role of the EGFR for the functioning of the immune system is discussed, alongside how EGFR antagonist treatment could be impacting tumor growth by blocking macrophage and FoxP3-expressing regulatory CD4+ T cell function. Based on these findings, we consider implications for current treatment schemes and suggest novel approaches to improve the efficacy of EGFR antagonist treatment in the future. Finally, we propose potential ways to improve EGFR antagonists, in order to enhance their clinical efficacy whilst diminishing unwanted side effects.

Involved external institutions

How to cite

APA:

Macdonald, F., & Zaiss, D.M.W. (2017). The immune system's contribution to the clinical efficacy of EGFR antagonist treatment. Frontiers in Pharmacology, 8(AUG). https://doi.org/10.3389/fphar.2017.00575

MLA:

Macdonald, Felicity, and Dietmar M. W. Zaiss. "The immune system's contribution to the clinical efficacy of EGFR antagonist treatment." Frontiers in Pharmacology 8.AUG (2017).

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