Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing

Weiss KT, Fante M, Koehl G, Schreml J, Haubner F, Kreutz M, Haverkampf S, Berneburg M, Schreml S (2017)

Publication Type: Journal article, Review article

Publication year: 2017

Journal

Experimental Dermatology Wiley

Book Volume: 26

Pages Range: 127-132

Journal Issue: 2

DOI: 10.1111/exd.13209

Abstract

Dysregulation of pH is a feature of both tumor growth and tissue repair. In tumors, microenvironmental changes, like in lactate metabolism, lead to altered intra- and extracellular pH (pHi, pHe) and vice versa. In wounds, barrier disruption results in extensive variations in pHe on the wound surface. It is known that altered extracellular proton concentrations have a major impact on cell turnover and migration as well as on the metabolic activity of cells involved in tumor spread and wound closure. The proton-sensing G protein-coupled receptors (GPCRs) GPR4, GPR65 (TDAG8), GPR68 (OGR1) and GPR132 (G2A) are activated via a decrease in pHe and transduce this signal to molecular intracellular pathways. Based on the current knowledge, we speculate on the role of proton-sensing GPCRs in wound healing and on their potential as mechanistic linkers of tumor growth and tissue repair.

Involved external institutions

Universitätsklinikum Regensburg DE Germany (DE) Universität zu Köln DE Germany (DE)

How to cite

APA:

Weiss, K.T., Fante, M., Koehl, G., Schreml, J., Haubner, F., Kreutz, M.,... Schreml, S. (2017). Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing. Experimental Dermatology, 26(2), 127-132. https://doi.org/10.1111/exd.13209

MLA:

Weiss, Katharina T., et al. "Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing." Experimental Dermatology 26.2 (2017): 127-132.

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