Cellular Innate Immunity: An Old Game with New Players
Gasteiger G, D'Osualdo A, Schubert DA, Weber A, Bruscia EM, Hartl D (2017)
Publication Type: Journal article, Review article
Publication year: 2017
Journal
Book Volume: 9
Pages Range: 111-125
Journal Issue: 2
DOI: 10.1159/000453397
Abstract
Innate immunity is a rapidly evolving field with novel cell types and molecular pathways being discovered and paradigms changing continuously. Innate and adaptive immune responses are traditionally viewed as separate from each other, but emerging evidence suggests that they overlap and mutually interact. Recently discovered cell types, particularly innate lymphoid cells and myeloid-derived suppressor cells, are gaining increasing attention. Here, we summarize and highlight current concepts in the field, focusing on innate immune cells as well as the inflammasome and DNA sensing which appear to be critical for the activation and orchestration of innate immunity, and may provide novel therapeutic opportunities for treating autoimmune, autoinflammatory, and infectious diseases.
Involved external institutions
Albert-Ludwigs-Universität Freiburg
Germany (DE)
F. Hoffmann-La Roche Ltd
Switzerland (CH)
Eberhard Karls Universität Tübingen
Germany (DE)
Yale University
United States (USA) (US)
Germany (DE)
F. Hoffmann-La Roche Ltd
Switzerland (CH)
Eberhard Karls Universität Tübingen
Germany (DE)
Yale University
United States (USA) (US)
How to cite
APA:
Gasteiger, G., D'Osualdo, A., Schubert, D.A., Weber, A., Bruscia, E.M., & Hartl, D. (2017). Cellular Innate Immunity: An Old Game with New Players. Journal of Innate Immunity, 9(2), 111-125. https://dx.doi.org/10.1159/000453397
MLA:
Gasteiger, Georg, et al. "Cellular Innate Immunity: An Old Game with New Players." Journal of Innate Immunity 9.2 (2017): 111-125.
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