Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1
Hefter M, Lother J, Weiss E, Schmitt AL, Fliesser M, Einsele H, Loeffler J (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 55
Pages Range: 573-578
Journal Issue: 5
DOI: 10.1093/mmy/myw105
Abstract
Aspergillus fumigatus is an opportunistic fungal pathogen causing detrimental infections in immunocompromised individuals. Dendritic cells (DCs) are potent antigen-presenting cells and recognize the A. fumigatus cell wall component β-1,3 glucan via Dectin-1, followed by DCmaturation and cytokine release. Here, we demonstrate that human primary myeloid DCs (mDCs) interact with different morphotypes of A. fumigatus. Dectin-1 is expressed on mDCs and is down-regulated after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via this receptor. Blocking of Dectin-1, followed by stimulation with depleted zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40, CD80, HLA-DR and CCR7 on mDCs and led to decreased release of the cytokines TNF-α, IL-8, IL-1β and IL-10.
Involved external institutions
Germany (DE)How to cite
APA:
Hefter, M., Lother, J., Weiss, E., Schmitt, A.L., Fliesser, M., Einsele, H., & Loeffler, J. (2017). Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1. Medical Mycology, 55(5), 573-578. https://doi.org/10.1093/mmy/myw105
MLA:
Hefter, Maike, et al. "Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1." Medical Mycology 55.5 (2017): 573-578.
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