Cytomegalovirus disease in hematopoietic stem cell transplant patients: Current and future therapeutic options

Fuji S, Einsele H, Kapp M (2017)

Publication Type: Journal article, Review article

Publication year: 2017

Journal

Current Opinion in Infectious Diseases Lippincott, Williams & Wilkins

Book Volume: 30

Pages Range: 372-376

Journal Issue: 4

DOI: 10.1097/QCO.0000000000000375

Abstract

Purpose of review: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become one of the standard treatment for hematological diseases. Although the clinical outcome has improved significantly during the last decades, the morbidity and mortality after allo-HSCT are still obstacles to cure. Out of major morbidities, opportunistic virus infections such as cytomegalovirus (CMV) infection are important complications, in particular in patients who received human leukocyte antigen-mismatched HSCT. Here, we aim to summarize information about current and future therapeutic options in CMV disease after allo-HSCT. Recent findings: Recently, not only new drugs but also adoptive T-cell therapy are tested in the setting of clinical trials. CMV prophylaxis using letermovir significantly reduced the incidence of CMV disease in comparison to placebo in a phase III clinical trial. Meanwhile, adoptive T-cell therapies which are fully adapted to good manufacturing practice (GMP) conditions are now available. A recent multicenter study in Germany showed a promising result using Streptamer-isolated T-cell therapy. Summary: With the recent development of CMV-targeted therapy, treatment strategies of CMV infection would be further sophisticated in the near future.

Involved external institutions

Osaka International Cancer Institute / 大阪国際がん研究所 JP Japan (JP) Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Fuji, S., Einsele, H., & Kapp, M. (2017). Cytomegalovirus disease in hematopoietic stem cell transplant patients: Current and future therapeutic options. Current Opinion in Infectious Diseases, 30(4), 372-376. https://doi.org/10.1097/QCO.0000000000000375

MLA:

Fuji, Shigeo, Hermann Einsele, and Markus Kapp. "Cytomegalovirus disease in hematopoietic stem cell transplant patients: Current and future therapeutic options." Current Opinion in Infectious Diseases 30.4 (2017): 372-376.

BibTeX: Download