Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis

Krishnan S, Prise IE, Wemyss K, Schenck LP, Bridgeman HM, Mcclure FA, Zangerle-Murray T, O'Boyle C, Barbera TA, Mahmood F, Bowdish DME, Zaiss DMW, Grainger JR, Konkel JE (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Proceedings of the National Academy of Sciences of the United States of America National Academy of Sciences

Book Volume: 115

Pages Range: 10738-10743

Journal Issue: 42

DOI: 10.1073/pnas.1802320115

Abstract

γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by γδ T cells with a T cell receptor (TCR) repertoire that diversifies during development. Gingival γδ T cells accumulated rapidly after birth in response to barrier damage, and strikingly, their absence resulted in enhanced pathology inmurine models of the oral inflammatory disease periodontitis. Alterations in bacterial communities could not account for the increased disease severity seen in γδ T cell-deficient mice. Instead, gingival γδ T cells produced the wound healing associated cytokine amphiregulin, administration of which rescued the elevated oral pathology of tcrδ-/- mice. Collectively, our results identify γδ T cells as critical constituents of the immuno-surveillance network that safeguard gingival tissue homeostasis.

Involved external institutions

University of Manchester GB United Kingdom (GB) McMaster University CA Canada (CA) University of Edinburgh GB United Kingdom (GB)

How to cite

APA:

Krishnan, S., Prise, I.E., Wemyss, K., Schenck, L.P., Bridgeman, H.M., Mcclure, F.A.,... Konkel, J.E. (2018). Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 115(42), 10738-10743. https://doi.org/10.1073/pnas.1802320115

MLA:

Krishnan, Siddharth, et al. "Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis." Proceedings of the National Academy of Sciences of the United States of America 115.42 (2018): 10738-10743.

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