Annotated dendrograms for neurons from the larval fruit fly brain

Strauch M, Hartenstein V, Andrade IV, Cardona A, Merhof D (2018)

Publication Type: Conference contribution

Publication year: 2018

Publisher: Eurographics Association

Pages Range: 57-66

Conference Proceedings Title: VCBM 2018 - Eurographics Workshop on Visual Computing for Biology and Medicine

Event location: Granada, ESP

ISBN: 9783038680567

DOI: 10.2312/vcbm.20181229

Abstract

Recent advances in neuroscience have made it possible to reconstruct all neurons of an entire neural circuit in the larval fruit fly brain from serial electron microscopy image stacks. The reconstructed neurons are morphologically complex 3D graphs whose nodes are annotated with labels representing different types of synapses. Here, we propose a method to draw simplified, yet realistic 2D neuron sketches of insect neurons in order to help biologists formulate hypotheses on neural function at the microcircuit level. The sketches are dendrograms that capture a neuron’s branching structure and that preserve branch lengths, providing realistic estimates for distances and signal travel times between synapses. To improve readability of the often densely clustered synapse annotations, synapses are automatically summarized in local clusters of synapses of the same type and arranged to minimize label overlap. We show that two major neuron classes of an olfactory circuit in the larval fruit fly brain can be discriminated visually based on the dendrograms. Unsupervised and supervised data analysis reveals that class discrimination can be performed using morphological features derived from the dendrograms.

Involved external institutions

Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE) University of California Los Angeles (UCLA) US United States (USA) (US) Howard Hughes Medical Institute US United States (USA) (US)

How to cite

APA:

Strauch, M., Hartenstein, V., Andrade, I.V., Cardona, A., & Merhof, D. (2018). Annotated dendrograms for neurons from the larval fruit fly brain. In Anna Puig, Thomas Schultz, Anna Vilanova, Ingrid Hotz, Barbora Kozlikova, Pere-Pau Vazquez (Eds.), VCBM 2018 - Eurographics Workshop on Visual Computing for Biology and Medicine (pp. 57-66). Granada, ESP: Eurographics Association.

MLA:

Strauch, Martin, et al. "Annotated dendrograms for neurons from the larval fruit fly brain." Proceedings of the 2018 Eurographics Workshop on Visual Computing for Biology and Medicine, VCBM 2018, Granada, ESP Ed. Anna Puig, Thomas Schultz, Anna Vilanova, Ingrid Hotz, Barbora Kozlikova, Pere-Pau Vazquez, Eurographics Association, 2018. 57-66.

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